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Obesity, FTO gene variant, and energy intake in children.

作者信息

Jonsson Anna, Franks Paul W

出版信息

N Engl J Med. 2009 Apr 9;360(15):1571-2; author reply 1572. doi: 10.1056/NEJMc090017.

DOI:10.1056/NEJMc090017

PMID:19357416

Abstract

摘要

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Obesity, FTO gene variant, and energy intake in children.

N Engl J Med. 2009 Apr 9;360(15):1571-2; author reply 1572. doi: 10.1056/NEJMc090017.

An obesity-associated FTO gene variant and increased energy intake in children.

N Engl J Med. 2008 Dec 11;359(24):2558-66. doi: 10.1056/NEJMoa0803839.

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure.

Obesity (Silver Spring). 2008 Aug;16(8):1961-5. doi: 10.1038/oby.2008.318. Epub 2008 Jun 12.

FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity.

J Clin Endocrinol Metab. 2009 Apr;94(4):1281-7. doi: 10.1210/jc.2008-1199. Epub 2009 Jan 21.

Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans.

Int J Obes (Lond). 2009 Nov;33(11):1227-34. doi: 10.1038/ijo.2009.159. Epub 2009 Aug 18.

The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.

Curr Obes Rep. 2015 Mar;4(1):73-91. doi: 10.1007/s13679-015-0143-1.

FTO association and interaction with time spent sitting.

Int J Obes (Lond). 2016 Mar;40(3):411-6. doi: 10.1038/ijo.2015.190. Epub 2015 Sep 22.

FTO and obesity: a problem for a billion people.

J Neuroendocrinol. 2012 Feb;24(2):393-4. doi: 10.1111/j.1365-2826.2011.02254.x.

[The role of FTO gene polymorphism in the pathogenesis of obesity].

Pediatr Endocrinol Diabetes Metab. 2010;16(2):109-13.

Variation in the FTO gene influences food intake but not energy expenditure.

Exp Clin Endocrinol Diabetes. 2009 Apr;117(4):194-7. doi: 10.1055/s-0028-1087176. Epub 2008 Dec 3.

引用本文的文献

Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study.

Sci Rep. 2016 Jan 4;6:18672. doi: 10.1038/srep18672.

Behavioral and Environmental Modification of the Genetic Influence on Body Mass Index: A Twin Study.

Behav Genet. 2015 Jul;45(4):409-26. doi: 10.1007/s10519-015-9718-6. Epub 2015 Apr 18.

Genetic and epigenetic catalysts in early-life programming of adult cardiometabolic disorders.

Diabetes Metab Syndr Obes. 2014 Dec 1;7:575-86. doi: 10.2147/DMSO.S51433. eCollection 2014.

The effects of genetic variation in FTO rs9939609 on obesity and dietary preferences in Chinese Han children and adolescents.

PLoS One. 2014 Aug 11;9(8):e104574. doi: 10.1371/journal.pone.0104574. eCollection 2014.

Uncovering the biology of FTO.

Mol Metab. 2012 Aug 3;1(1-2):32-6. doi: 10.1016/j.molmet.2012.06.001. eCollection 2012.

Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.

PLoS Genet. 2013;9(7):e1003607. doi: 10.1371/journal.pgen.1003607. Epub 2013 Jul 25.

The biology of FTO: from nucleic acid demethylase to amino acid sensor.

Diabetologia. 2013 Oct;56(10):2113-21. doi: 10.1007/s00125-013-2999-5. Epub 2013 Jul 30.

Genetic instrumental variable studies of effects of prenatal risk factors.

Biodemography Soc Biol. 2013;59(1):4-36. doi: 10.1080/19485565.2013.774615.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.

FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

Front Endocrinol (Lausanne). 2011 Feb 22;2:4. doi: 10.3389/fendo.2011.00004. eCollection 2011.

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相似文献

Obesity, FTO gene variant, and energy intake in children.

N Engl J Med. 2009 Apr 9;360(15):1571-2; author reply 1572. doi: 10.1056/NEJMc090017.

An obesity-associated FTO gene variant and increased energy intake in children.

N Engl J Med. 2008 Dec 11;359(24):2558-66. doi: 10.1056/NEJMoa0803839.

Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure.

Obesity (Silver Spring). 2008 Aug;16(8):1961-5. doi: 10.1038/oby.2008.318. Epub 2008 Jun 12.

FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity.

J Clin Endocrinol Metab. 2009 Apr;94(4):1281-7. doi: 10.1210/jc.2008-1199. Epub 2009 Jan 21.

Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans.

Int J Obes (Lond). 2009 Nov;33(11):1227-34. doi: 10.1038/ijo.2009.159. Epub 2009 Aug 18.

The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.

Curr Obes Rep. 2015 Mar;4(1):73-91. doi: 10.1007/s13679-015-0143-1.

FTO association and interaction with time spent sitting.

Int J Obes (Lond). 2016 Mar;40(3):411-6. doi: 10.1038/ijo.2015.190. Epub 2015 Sep 22.

FTO and obesity: a problem for a billion people.

J Neuroendocrinol. 2012 Feb;24(2):393-4. doi: 10.1111/j.1365-2826.2011.02254.x.

[The role of FTO gene polymorphism in the pathogenesis of obesity].

Pediatr Endocrinol Diabetes Metab. 2010;16(2):109-13.

Variation in the FTO gene influences food intake but not energy expenditure.

Exp Clin Endocrinol Diabetes. 2009 Apr;117(4):194-7. doi: 10.1055/s-0028-1087176. Epub 2008 Dec 3.

引用本文的文献

Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study.

Sci Rep. 2016 Jan 4;6:18672. doi: 10.1038/srep18672.

Behavioral and Environmental Modification of the Genetic Influence on Body Mass Index: A Twin Study.

Behav Genet. 2015 Jul;45(4):409-26. doi: 10.1007/s10519-015-9718-6. Epub 2015 Apr 18.

Genetic and epigenetic catalysts in early-life programming of adult cardiometabolic disorders.

Diabetes Metab Syndr Obes. 2014 Dec 1;7:575-86. doi: 10.2147/DMSO.S51433. eCollection 2014.

The effects of genetic variation in FTO rs9939609 on obesity and dietary preferences in Chinese Han children and adolescents.

PLoS One. 2014 Aug 11;9(8):e104574. doi: 10.1371/journal.pone.0104574. eCollection 2014.

Uncovering the biology of FTO.

Mol Metab. 2012 Aug 3;1(1-2):32-6. doi: 10.1016/j.molmet.2012.06.001. eCollection 2012.

Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry.

PLoS Genet. 2013;9(7):e1003607. doi: 10.1371/journal.pgen.1003607. Epub 2013 Jul 25.

The biology of FTO: from nucleic acid demethylase to amino acid sensor.

Diabetologia. 2013 Oct;56(10):2113-21. doi: 10.1007/s00125-013-2999-5. Epub 2013 Jul 30.

Genetic instrumental variable studies of effects of prenatal risk factors.

Biodemography Soc Biol. 2013;59(1):4-36. doi: 10.1080/19485565.2013.774615.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.

FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

Front Endocrinol (Lausanne). 2011 Feb 22;2:4. doi: 10.3389/fendo.2011.00004. eCollection 2011.

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Obesity, FTO gene variant, and energy intake in children.

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