Pant Harshita, Schembri Mark A, Wormald Peter J, Macardle Peter J
Department of Otorhinolaryngology Head and Neck Surgery, the University of Adelaide, Adelaide, Australia.
Laryngoscope. 2009 Jun;119(6):1046-52. doi: 10.1002/lary.20170.
This review will address the current knowledge of the pathogenic mechanisms in allergic fungal sinusitis (AFS) and the basis for the current classification of a subgroup of chronic rhinosinusitis patients. Special attention is directed to the role of immunoglobulin E (IgE)-mediated fungal allergy in the pathogenesis of AFS. Concepts relating to the mucosal inflammatory response are introduced, as a knowledge of the reactions of the sinus mucosal cells can lead to a better understanding of the mechanisms perpetuating and maintaining the chronic inflammation. Laryngoscope, 2009.
本综述将阐述变应性真菌性鼻窦炎（AFS）致病机制的当前认知以及慢性鼻窦炎患者一个亚组当前分类的依据。特别关注免疫球蛋白E（IgE）介导的真菌过敏在AFS发病机制中的作用。还将介绍与黏膜炎症反应相关的概念，因为了解鼻窦黏膜细胞的反应有助于更好地理解使慢性炎症持续存在和维持的机制。《喉镜》，2009年。
