Hashemian Farnaz, Baghbanian Neda, Majd Zahra, Rouini Mohammad-Reza, Jahanshahi Javaneh, Hashemian Farshad
Department of Otolaryngology, Hamadan University of Medical Sciences, Hamadan, Iran.
Eur Arch Otorhinolaryngol. 2015 Jun;272(6):1429-35. doi: 10.1007/s00405-014-3233-x. Epub 2014 Aug 9.
Chronic rhinosinusitis is a common disease which causes persisting inflammatory conditions of one or more sinuses. This study was designed to evaluate the effect of thyme honey nasal spray as an adjunctive medication on chronic rhinosinusitis after functional endoscopic sinus surgery. This was a randomized, placebo controlled, double-blind clinical study. 64 patients with chronic rhinosinusitis undergoing functional endoscopic sinus surgery were enrolled in this study. Patients were randomized and blinded to receive either placebo or thyme honey nasal spray in addition to the standard regimen postoperatively. Patients were visited on postoperative days 7, 30 and 60. The sino-nasal outcome test, endoscopic grading system and sinus CT-scan were scored before operation and on the day 60 after surgery. 54 patients completed the study. Significant improvement was observed in both treatment groups. There were no significant changes in SNOT-22, endoscopy and CT-scan scores between the two study groups. However, a greater reduction in endoscopic scores was shown in thyme honey group. The incidence of adverse effects was not significantly different between the groups, but synechiae formation and epistaxis were lower in treatment group. Thyme honey nasal spray seems to be a low-priced potential adjuvant remedy with excellent safety profile, to reduce inflammation and polyp formation and also fostering mucosal healing for patients suffering from chronic rhinosinusitis. However, further studies are recommended.
慢性鼻窦炎是一种常见疾病，可导致一个或多个鼻窦持续存在炎症状态。本研究旨在评估百里香蜂蜜滴鼻剂作为辅助药物在功能性鼻内镜鼻窦手术后对慢性鼻窦炎的疗效。这是一项随机、安慰剂对照、双盲临床研究。64例接受功能性鼻内镜鼻窦手术的慢性鼻窦炎患者纳入本研究。患者被随机分组并设盲，术后除接受标准治疗方案外，分别给予安慰剂或百里香蜂蜜滴鼻剂。在术后第7天、30天和60天对患者进行随访。术前及术后第60天对鼻窦结局测试、内镜分级系统和鼻窦CT扫描进行评分。54例患者完成了研究。两个治疗组均观察到显著改善。两个研究组之间的鼻窦症状测试-22、内镜检查和CT扫描评分均无显著变化。然而，百里香蜂蜜组的内镜评分下降幅度更大。两组不良反应发生率无显著差异，但治疗组粘连形成和鼻出血的发生率较低。百里香蜂蜜滴鼻剂似乎是一种价格低廉的潜在辅助治疗药物，具有良好的安全性，可减轻慢性鼻窦炎患者的炎症和息肉形成，并促进黏膜愈合。然而，建议进一步开展研究。
