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[单独及联合接触化学物质和电离辐射后的染色体畸变]

[Chromosomal aberrations upon isolated and combined exposures to chemical substances and ionizing irradiation].

作者信息

Barantseva M Iu, Mukhamedieva L N, Fedorenko B S, Vorozhtsova S V

出版信息

Gig Sanit. 2009 Jan-Feb(1):67-70.

PMID:19358360
Abstract

The partial summation of biological effects evaluated by the anaphasic chromosomal aberration test in the bone marrow karyocytes of mice was determined when the animals were concurrently exposed to chemical substances (acetone, acetaldehyde, ammonia, and ethanol) at low concentrations and gamma-irradiation in a total dose of 30 Gy. Qualitative analysis of chromosomal aberrations in the karyocytes of the bone marrow (ponses, fragments) has indicated that upon combined exposure of the animals to the chemical substances and gamma-irradiation, the chemical factor is dominant since upon combined radiochemical exposure, the number of chromosomal aberration increases mainly at the expense of fragments (91.2%), as does upon isolated exposure to chemical substances (96.4%).

摘要

当小鼠同时暴露于低浓度化学物质(丙酮、乙醛、氨和乙醇)和总剂量为30 Gy的γ辐射时,测定了通过小鼠骨髓核细胞的后期染色体畸变试验评估的生物学效应的部分总和。对骨髓核细胞中的染色体畸变(桥、片段)进行的定性分析表明,当动物同时暴露于化学物质和γ辐射时,化学因素占主导地位,因为在联合放射化学暴露时,染色体畸变数量的增加主要以片段(91.2%)为代价,单独暴露于化学物质时也是如此(96.4%)。

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