Tatarkin S V, Shafirkin A V, Barantseva M Iu, Mukhamedieva L N
Aviakosm Ekolog Med. 2013 Sep-Oct;47(5):31-6.
The article presents data on chromosomal aberrations in bone marrow cells of mice following isolated exposure to gamma-radiation and chemical factor within the existing MPCs for piloted spacecraft, and also combined sequential exposure in the ranges predicted for interplanetary missions. In the event of chronic exposure the relative number of chromosomal aberrations goes up till reaching plateau and is governed strictly by the mathematical dependence on effective residual gamma-dose and effective damage of organism from inhaled chemical factor. Sequential exposure to the radiation and chemical factors within the ranges specified for orbital and remote space missions caused a tangible reduction of the speed of cytogenetic damages reparation in postexposure period which may be interpreted as depletion of the body reserve and compensatory-recovery potential.
本文介绍了在载人航天器现有最大允许浓度（MPC）范围内，小鼠骨髓细胞在单独暴露于γ辐射和化学因子后，以及在星际任务预测范围内进行联合顺序暴露后的染色体畸变数据。在慢性暴露情况下，染色体畸变的相对数量会上升直至达到平稳状态，并且严格受有效残余γ剂量和吸入化学因子对机体有效损伤的数学依赖关系所支配。在轨道和深空任务规定的范围内，顺序暴露于辐射和化学因子会导致暴露后时期细胞遗传学损伤修复速度明显降低，这可解释为机体储备和代偿恢复潜力的耗尽。
