Buc M, Rovenský J
Imunologický ustav Lekárskej fakulty UK, Bratislava.
Epidemiol Mikrobiol Imunol. 2009 Feb;58(1):3-14.
Systemic lupus erythematosus (SLE) is an organ non-specific autoimmune disorder, with multiple immunopathogenic mechanisms being implicated in its development. The most conspicuous feature of the disease is an exaggerated synthesis of various types of autoantibodies, followed by the formation of immune complexes that deposit in tissues and elicit an inflammatory response. Apart from antibodies, dendritic cells, T cells and cytokines are substantially involved in the pathogenesis of SLE and class I interferons seem to play a crucial role. SLE is a genetically determined disease. HLA system and complement system genes, apoptosis regulating genes and IgG Fc-gamma receptor genes are among the multiple genes implicated in SLE. The role of hormones, both estrogen and progesterone, in SLE activity has been reported. Some monoclonal antibodies have recently proved effective in the treatment of SLE.
系统性红斑狼疮（SLE）是一种器官非特异性自身免疫性疾病，其发病涉及多种免疫致病机制。该疾病最显著的特征是各类自身抗体过度合成，随后形成免疫复合物沉积于组织并引发炎症反应。除抗体外，树突状细胞、T细胞和细胞因子在SLE发病机制中也发挥着重要作用，I类干扰素似乎起着关键作用。SLE是一种由基因决定的疾病。HLA系统和补体系统基因、细胞凋亡调节基因以及IgG Fc-γ受体基因等多种基因与SLE有关。雌激素和孕激素等激素在SLE活动中的作用也有相关报道。最近，一些单克隆抗体已被证明对SLE治疗有效。
