Park Jin-Young, Lee Yoon-Suk, Chang Byoung-Yong, Karthikeyan S, Kim Kwang S, Kim Byeang Hyean, Park Su-Moon
Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Korea.
Anal Chem. 2009 May 15;81(10):3843-50. doi: 10.1021/ac900220n.
A highly selective receptor for serotonin was designed using cages formed by the (R)-lipo-diaza-18-crown-6 self-assembled monolayer (SAM) on gold and experimentally verified by a variety of electrochemical experiments in solutions containing large amounts of dopamine and ascorbic acid, as well as other interferents. The molecular modeling study showed that parameters such as the H-pi interaction provided important driving forces for the cage to form a strong inclusion complex with serotonin. The charge-transfer resistance (R(CT)'s) to/from redox probe ions, Fe(CN)(6)(3-/4-), was greatly enhanced because of their electrostatic attractions to ammonium ions of serotonin molecules captured by cages. The changes in R(CT)-values were shown to be remarkably selective for serotonin in the presence of many interferents.
利用由（R）-脂基二氮杂-18-冠-6在金表面自组装单层（SAM）形成的笼状结构设计了一种高选择性血清素受体，并通过在含有大量多巴胺、抗坏血酸以及其他干扰物的溶液中进行的各种电化学实验进行了实验验证。分子模拟研究表明，诸如H-π相互作用等参数为笼状结构与血清素形成强包合物提供了重要驱动力。由于氧化还原探针离子Fe(CN)₆³⁻/⁴⁻与被笼状结构捕获的血清素分子的铵离子之间的静电吸引，其与氧化还原探针离子之间的电荷转移电阻（R(CT)）大大增强。结果表明，在存在许多干扰物的情况下，R(CT)值的变化对血清素具有显著的选择性。
