Parvizi Josef, Coburn Kerry L, Shillcutt Samuel D, Coffey C Edward, Lauterbach Edward C, Mendez Mario F
Department of Neurology, Stanford University School of Medicine, Stanford, CA 94305, USA.
J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):75-87. doi: 10.1176/jnp.2009.21.1.75.
Pathological laughing and crying (PLC) is a clinical condition that occurs in patients with various neurological disorders. It is characterized by the presence of episodic and contextually inappropriate or merely exaggerated outbursts of laughter and/or crying without commensurate feelings. This review provides an in depth analysis of the neuroanatomy of lesions seen in patients with this clinical condition, discusses the relevant functional neuroimaging and electrophysiological stimulation studies in human subjects, and summarizes the current treatment options. It concludes with a presentation of the remaining questions and directions for future research.
病理性哭笑（PLC）是一种发生于各种神经系统疾病患者的临床病症。其特征为出现发作性且与情境不符或仅仅是夸张的大笑和/或大哭发作，且没有相应的情感。本综述对患有这种临床病症的患者所见到的病变神经解剖学进行了深入分析，讨论了在人类受试者中相关的功能神经影像学和电生理刺激研究，并总结了当前的治疗选择。最后提出了剩余的问题以及未来研究的方向。
