Kiladze M, Gorgoshidze M, Monaselidze J, Jokhadze T, Lezhava T
E. Andronikashvili Institute of Physics, Tbilisi. Georgia.
Georgian Med News. 2009 Mar(168):104-7.
Research goal was study of separate and joint influence of bioregulator prostamax and Cu(II) and Cd(II) ions on the chromatin structure in situ. The thermal characteristics of the denaturation process of blood lymphocytes culture of aging people in the presence of some microg quantities of Cu(II) and Cd(II) ions have been determined. It has been shown that Cu(II) and Cd(II) ions at these low concentrations don't influence on the temperature stability of membrane, nuclear and cytoplasm proteins. It has been shown that Cu(II) ions cause an additional condensation of the heterochromatin, and Cd(II) ions cause decondensation of heterochromatin and its partial denaturation.
研究目标是原位研究生物调节剂前列腺素和铜（II）离子及镉（II）离子的单独和联合作用对染色质结构的影响。已测定了在存在微量铜（II）离子和镉（II）离子的情况下老年人血液淋巴细胞培养物变性过程的热特性。结果表明，这些低浓度的铜（II）离子和镉（II）离子对膜、核和细胞质蛋白质的温度稳定性没有影响。结果表明，铜（II）离子会导致异染色质额外浓缩，而镉（II）离子会导致异染色质解聚及其部分变性。
