Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing beta-ketoesters.

Organocatalytic enantioselective conjugate addition of alpha-fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.