与叔立体中心相邻的含氟季碳的不对称生成：氟化次甲基作为亲核试剂的用途。
Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles.
作者信息
Han Xiao, Luo Jie, Liu Chen, Lu Yixin
机构信息
Department of Chemistry, National University of Singapore, Singapore, Republic of Singapore.
出版信息
Chem Commun (Camb). 2009 Apr 21(15):2044-6. doi: 10.1039/b823184b. Epub 2009 Feb 26.
DOI:10.1039/b823184b
PMID:19333485
Abstract
Organocatalytic asymmetric Michael reactions of fluorinated nucleophiles with nitroolefins catalyzed by Cinchona alkaloid-derived thiourea catalysts generated the desired Michael products containing vicinal fluorinated quaternary and tertiary chiral centers with exceptional enantioselectivity.
摘要
由金鸡纳生物碱衍生的硫脲催化剂催化的含氟亲核试剂与硝基烯烃的有机催化不对称迈克尔反应，以优异的对映选择性生成了含有相邻氟代季碳和叔碳手性中心的目标迈克尔产物。
Zotero 插件