Lacko Martin, Oude Ophuis Michael B, Peters Wilbert H M, Manni Johannes J
Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Maastricht, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
Anticancer Res. 2009 Feb;29(2):753-61.
Smoking and the consumption of alcohol are the main risk factors for head and neck cancer. However, interindividual variation in the activity of enzymes involved in the detoxification of tobacco smoke (pro)carcinogens, such as microsomal epoxide hydrolase (mEH), glutathione-S-transferases (GSTs) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase (UGTs), may influence the process of carcinogenesis. Genetic polymorphisms of these enzymes may alter their activity and may thus modulate the risk for squamous cell carcinomas of the head and neck (SCCHN). A literature review on the role of mEH, GSTs and UGTs polymorphisms in relation to SCCHN was performed and the results summarized. For mEH polymorphisms, some of the studies revealed a relationship between genetic polymorphisms of these enzymes and an altered risk for SCCHN, whereas others did not. The presence of null polymorphisms in GSTM1 or GSTT1 were associated with an increased risk for SCCHN. For the UGTs, only variants in UGT1A7 and UGT1A10 have been studied, both of which were associated with an altered risk for SCCHN.
吸烟和饮酒是头颈癌的主要危险因素。然而，参与烟草烟雾（前）致癌物解毒的酶（如微粒体环氧化物水解酶（mEH）、谷胱甘肽-S-转移酶（GSTs）和尿苷5'-二磷酸（UDP）-葡萄糖醛酸基转移酶（UGTs））的活性存在个体差异，这可能会影响致癌过程。这些酶的基因多态性可能会改变它们的活性，从而可能调节头颈部鳞状细胞癌（SCCHN）的风险。我们对mEH、GSTs和UGTs基因多态性与SCCHN的关系进行了文献综述，并总结了结果。对于mEH基因多态性，一些研究揭示了这些酶的基因多态性与SCCHN风险改变之间的关系，而其他研究则没有。GSTM1或GSTT1中无效多态性的存在与SCCHN风险增加有关。对于UGTs，仅研究了UGT1A7和UGT1A10中的变体，两者均与SCCHN风险改变有关。
