Tsuchiya Atsunori, Imai Michitaka, Kamimura Hiroteru, Togashi Tadayuki, Watanabe Kouji, Seki Kei, Ishikawa Toru, Ohta Hironobu, Yoshida Toshiaki, Kamimura Tomoteru
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata, Japan.
World J Gastroenterol. 2009 Apr 14;15(14):1779-81. doi: 10.3748/wjg.15.1779.
We report the successful treatment of multiple lung metastases after hepatic resection for hepatocellular carcinoma (HCC) with combined docetaxel, cisplatin (CDDP), and enteric-coated tegafur/uracil (UFT-E). A 68-year-old man was diagnosed with multiple lung metastases of HCC 7 mo after partial hepatectomy for HCC. Oral UFT-E was given daily and docetaxel and CDDP were given intra-arterially (administered just before the bronchial arteries) every 2 wk via a subcutaneous injection port. One month after starting chemotherapy, levels of tumor marker, protein induced by vitamin K absence II (PIVKA-II), decreased rapidly, and after a further month, chest X-ray and computed tomography revealed the complete disappearance of multiple liver metastases. Two years after the combined chemotherapy, HCC recurred in the liver and was treated but no pulmonary recurrence occurred. In the absence of a standardized highly effective therapy, this combined chemotherapy with docetaxel, CDDP and UFT-E may be an attractive option for multiple lung metastases of HCC.
我们报告了采用多西他赛、顺铂（CDDP）和替加氟尿嘧啶肠溶制剂（UFT-E）联合治疗肝细胞癌（HCC）肝切除术后多发肺转移的成功案例。一名68岁男性在接受HCC部分肝切除术后7个月被诊断为HCC多发肺转移。每天口服UFT-E，多西他赛和顺铂每2周通过皮下注射端口经动脉内给药（在支气管动脉前给药）。开始化疗1个月后，肿瘤标志物维生素K缺乏诱导蛋白II（PIVKA-II）水平迅速下降，再过1个月后，胸部X线和计算机断层扫描显示多发肝转移完全消失。联合化疗2年后，肝脏出现HCC复发并接受了治疗，但未发生肺复发。在缺乏标准化高效疗法的情况下，这种多西他赛、CDDP和UFT-E联合化疗可能是HCC多发肺转移的一种有吸引力的选择。
