来自糖芥蝇子草的小蜡烷二萜。

Minor labdane diterpenes from Marrubium thessalum.

机构信息

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-15771, Athens.

出版信息

Chem Biodivers. 2011 Oct;8(10):1880-90. doi: 10.1002/cbdv.201000215.

DOI:10.1002/cbdv.201000215

PMID:22006716

Abstract

Five new labdane diterpenes, thessalines A, B, and D, 14β-hydroxythessaline A, and 14β-hydroxythessaline B (1-5, resp.) were isolated from the aerial parts of Marrubium thessalum, along with the known labdane diterpene deacetylvitexilactone (6) and the methoxylated flavones 4',7-dimethylapigenin and salvigenin. (3S,5R)-Loliolide was also found in the same source. Their structures were established by 1D- and 2D-NMR (COSY, HSQC, HMBC, NOESY, and ROESY) and MS analyses. The plant produces a great variety of labdane-type diterpenes, with variations in functionalities, particularly in the side chain. Their structures could be of chemotaxonomic significance for the genus Marrubium.

摘要

从马郁兰（Marrubium thessalum）的地上部分分离得到了 5 个新的贝壳杉烷二萜，分别为 thessalines A、B 和 D、14β-羟基 thessaline A 和 14β-羟基 thessaline B（1-5，分别），以及已知的贝壳杉烷二萜去乙酰基 vitexilactone（6）和甲氧基化黄酮 4'，7-二甲基芹菜素和 savigenin。在同一来源中还发现了（3S，5R）-丁香螺内酯。通过 1D 和 2D-NMR（COSY、HSQC、HMBC、NOESY 和 ROESY）和 MS 分析确定了它们的结构。该植物产生了大量的贝壳杉烷型二萜，其功能存在差异，特别是在侧链上。它们的结构可能对马郁兰属具有化学生态分类学意义。