Kooijman Edgar Eduard, Burger Koert N J
Department of Biological Sciences, Kent State University, Kent, OH, USA.
Biochim Biophys Acta. 2009 Sep;1791(9):881-8. doi: 10.1016/j.bbalip.2009.04.001. Epub 2009 Apr 9.
Phosphatidic acid is the simplest (diacyl)glycerophospholipid present in cells and is now a well established second messenger with direct biological functions. It is specifically recognized by diverse proteins and plays an important role in cellular signaling and membrane dynamics in all eukaryotes. An important determinant of the biological functions of phosphatidic acid is its anionic headgroup. In this review we will focus on the peculiar ionization properties of phosphatidic acid and their crucial role in lipid-protein interactions. We will take a molecular approach focusing entirely on the physical chemistry of the lipid and develop a model explaining the ionization properties of phosphatidic acid, termed the electrostatic-hydrogen bond switch model. Diverse examples from recent literature in support of this model will be presented and the broader implications of our findings will be discussed.
磷脂酸是细胞中存在的最简单的（二酰基）甘油磷脂，现在是一种具有直接生物学功能的成熟的第二信使。它能被多种蛋白质特异性识别，并在所有真核生物的细胞信号传导和膜动力学中发挥重要作用。磷脂酸生物学功能的一个重要决定因素是其阴离子头部基团。在本综述中，我们将重点关注磷脂酸独特的电离特性及其在脂-蛋白相互作用中的关键作用。我们将采用完全聚焦于脂质物理化学的分子方法，建立一个解释磷脂酸电离特性的模型，即静电-氢键开关模型。将展示近期文献中支持该模型的各种实例，并讨论我们研究结果的更广泛意义。
