Kasukabe T, Okabe-Kado J, Honma Y, Hozumi M
Department of Chemotherapy, Saitama Cancer Center Research Institute, Japan.
FEBS Lett. 1991 Oct 21;291(2):181-4. doi: 10.1016/0014-5793(91)81278-g.
The effects of interleukin-4(IL-4) on the growth and differentiation of mouse myeloid leukemia M1 cells induced by various differentiation inducers were investigated. IL-4 alone did not have any significant effect on the growth or differentiation of M1 cells, but inhibited their differentiation induced by dexamethasone, D-factor/leukemia inhibitory factor, or interleukin 6. IL-4 also restored the proliferation of M1 cells after growth inhibition during their induction of differentiation by inducers. In contrast, IL-4 enhanced inhibition of growth and induction of differentiation of M1 cells by 1 alpha,25-dihydroxyvitamin D3. These results indicate that modulation of differentiation of M1 cells by IL-4 depends on the differentiation inducer.
研究了白细胞介素-4（IL-4）对多种分化诱导剂诱导的小鼠髓性白血病M1细胞生长和分化的影响。单独的IL-4对M1细胞的生长或分化没有任何显著影响，但可抑制地塞米松、D因子/白血病抑制因子或白细胞介素6诱导的M1细胞分化。在诱导剂诱导M1细胞分化过程中，生长受到抑制后，IL-4还可恢复M1细胞的增殖。相反，IL-4增强了1α,25-二羟基维生素D3对M1细胞生长的抑制和分化的诱导。这些结果表明，IL-4对M1细胞分化的调节取决于分化诱导剂。
