Jiang Hong, Liu Jin-tao, Hui Reng-hua, Wang Yong-jun
The Institute of Spinal Disease, the Shanghai University of TCM, 201203, Shanghai, China.
Zhongguo Gu Shang. 2009 Mar;22(3):205-7.
To investigate the possible mechanism of immune response in the resorption of the ruptured intervertebral disc herniation, and the possible mechanism of radix astragali on the resorption of the ruptured disc herniation.
Twenty-eight male SD (Sprague-dawley) rats were chosen. The rats were randomly divided into 4 groups: the control group, model group, the group treated with radix astragali injection and the group treated whit thymic peptide. The rats were killed and discs were harvested 10 days after treatment. Flow cytometry and HE staining were used for analysis of cells and tissue.
Compared with the control group, the proportion of activated T cells (CD4+ and CD8+) and B cells were significantly higher in the two drug-treatment groups.
Herniated nucleus pulposus attracts activated T and B cells and triggered an immune response. Radix astragali could strengthen the autoimmune response.
探讨破裂型椎间盘突出症吸收过程中免疫反应的可能机制，以及黄芪对破裂型椎间盘突出症吸收的可能机制。
选取28只雄性SD（Sprague-dawley）大鼠。将大鼠随机分为4组：对照组、模型组、黄芪注射液治疗组和胸腺肽治疗组。治疗10天后处死大鼠并采集椎间盘。采用流式细胞术和苏木精-伊红染色对细胞和组织进行分析。
与对照组相比，两个药物治疗组中活化T细胞（CD4+和CD8+）和B细胞的比例显著更高。
髓核突出吸引活化的T和B细胞并引发免疫反应。黄芪可增强自身免疫反应。
