Chen Lin, Huang Hongyun
Beijing Hongtianji Neuroscience Academy, Department of Neurosurgery, Beijing Rehabilitation Center, Beijing, 100144, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009 Mar;23(3):366-70.
To elucidate the new concept and theory of neurorestoratology.
With the review of the development course and important research works in the field of neurorestoratology during the 20th century, especially recent 30 years, the regularity summary, science and technology philosophy induction, and theory distillation were carried out in this article.
The new discipline system was brought forward as follows: (1) DEFINITION: neurorestoratology was a sub-discipline of neuroscience which studies neural regeneration, neural structural repair of replacement, neuroplasticity and neuromodulation. The core purpose was to promote neural functional recovery of all neural degenerative diseases and damages. (2) One central task and two basic points: to recover neurological function was the central research task all the time and the two basic points were the preclinical (basic) neuro restoration and the clinical neuro restoration. (3) Four rationale of the discipline: limited renovation, relearning, insufficient reserve, and lifelong reinforcement. (4) Five major factors of neurorestoratology (5N's dogma): neuroregeneration, neurorepair, neuroplasticity, neuromodulation, neurorehabilitation. "Neuroprotection" appeared to be included in the broad definition. (5) Four-step rule of neurorestoratology: structural neuro restoration, signal neuro restoration, rehabilitative neuro restoration, and functional neuro restoration. (6) Emphasize that translational medicine from lab to bed in neuro restoration.
The discipline of neurorestoratology has the vast development prospect and will be sure to increase the rapid progress of the basic and clinical restorative neuroscience.
阐明神经修复学的新概念和理论。
通过回顾20世纪，尤其是近30年神经修复学领域的发展历程和重要研究工作，进行规律性总结、科技哲学归纳及理论提炼。
提出了新的学科体系如下：（1）定义：神经修复学是神经科学的一个子学科，研究神经再生、神经结构的修复或替代、神经可塑性和神经调制。核心目的是促进所有神经退行性疾病和损伤的神经功能恢复。（2）一个中心任务和两个基本点：恢复神经功能始终是核心研究任务，两个基本点是临床前（基础）神经修复和临床神经修复。（3）学科的四个理论基础：有限修复、重新学习、储备不足和终身强化。（4）神经修复学的五个主要因素（5N原则）：神经再生、神经修复、神经可塑性、神经调制、神经康复。广义定义中似乎包含“神经保护”。（5）神经修复学的四步规则：结构神经修复、信号神经修复、康复神经修复和功能神经修复。（6）强调神经修复领域从实验室到临床的转化医学。
神经修复学学科具有广阔的发展前景，必将推动基础和临床修复神经科学的快速发展。
