[Neurorestoratology: new concept and bridge from bench to bedside].

OBJECTIVE

To elucidate the new concept and theory of neurorestoratology.

METHODS

With the review of the development course and important research works in the field of neurorestoratology during the 20th century, especially recent 30 years, the regularity summary, science and technology philosophy induction, and theory distillation were carried out in this article.

RESULTS

The new discipline system was brought forward as follows: (1) DEFINITION: neurorestoratology was a sub-discipline of neuroscience which studies neural regeneration, neural structural repair of replacement, neuroplasticity and neuromodulation. The core purpose was to promote neural functional recovery of all neural degenerative diseases and damages. (2) One central task and two basic points: to recover neurological function was the central research task all the time and the two basic points were the preclinical (basic) neuro restoration and the clinical neuro restoration. (3) Four rationale of the discipline: limited renovation, relearning, insufficient reserve, and lifelong reinforcement. (4) Five major factors of neurorestoratology (5N's dogma): neuroregeneration, neurorepair, neuroplasticity, neuromodulation, neurorehabilitation. "Neuroprotection" appeared to be included in the broad definition. (5) Four-step rule of neurorestoratology: structural neuro restoration, signal neuro restoration, rehabilitative neuro restoration, and functional neuro restoration. (6) Emphasize that translational medicine from lab to bed in neuro restoration.

CONCLUSION

The discipline of neurorestoratology has the vast development prospect and will be sure to increase the rapid progress of the basic and clinical restorative neuroscience.