人特应性皮炎和变应性接触性皮炎皮肤中 COUP-TF 相互作用蛋白 2（CTIP2）的表达。
Expression of COUP-TF-interacting protein 2 (CTIP2) in human atopic dermatitis and allergic contact dermatitis skin.
出版信息
Exp Dermatol. 2009 Nov;18(11):994-6. doi: 10.1111/j.1600-0625.2009.00876.x. Epub 2009 Mar 29.
Abstract
Chicken ovalbumin upstream promoter-transcription factor-interacting protein 2 (CTIP2) is a transcriptional regulator that is highly expressed in skin during mouse development, as well as in proliferating cells of adult mouse skin. We investigated expression of CTIP2 along with proliferation marker Ki-67 in normal human skin, and in skin from atopic dermatitis (AD), and in allergic contact dermatitis (ACD) samples by immunohistochemistry (IHC). We discovered for the first time that CTIP2 was expressed in proliferating basal and suprabasal layer in normal human epidermis. CTIP2 expression was dramatically increased in the epidermis from the AD and ACD samples compared with normal samples, and was labelled in both proliferating basal and suprabasal layers. Altogether our results suggest that CTIP2 expression could be linked to disease progression and/or maintenance in AD and ACD patients.
摘要
鸡卵清蛋白上游启动子转录因子相互作用蛋白 2（CTIP2）是一种转录调节因子，在小鼠发育过程中皮肤中高度表达，在成年小鼠皮肤的增殖细胞中也高度表达。我们通过免疫组织化学（IHC）研究了 CTIP2 与增殖标志物 Ki-67 在正常人类皮肤、特应性皮炎（AD）皮肤和变应性接触性皮炎（ACD）样本中的表达。我们首次发现 CTIP2 在正常人类表皮的增殖基底和超基底层中表达。与正常样本相比，AD 和 ACD 样本中的表皮中 CTIP2 的表达显著增加，并在增殖的基底和超基底层中均有标记。总的来说，我们的结果表明 CTIP2 的表达可能与 AD 和 ACD 患者的疾病进展和/或维持有关。
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