Daher Marie-Thérèse, Bausero Pedro, Agbulut Onnik, Li Zhenlin, Parlakian Ara
Biological Adaptation and Ageing, Inserm ERL U1164, UMR CNRS 8256, Institut de Biologie Paris-Seine, Sorbonne Université, Paris, France.
Front Cell Dev Biol. 2020 Dec 10;8:581674. doi: 10.3389/fcell.2020.581674. eCollection 2020.
Ctip2/Bcl11b is a zinc finger transcription factor with dual action (repression/activation) that couples epigenetic regulation to gene transcription during the development of various tissues. It is involved in a variety of physiological responses under healthy and pathological conditions. Its role and mechanisms of action are best characterized in the immune and nervous systems. Furthermore, its implication in the development and homeostasis of other various tissues has also been reported. In the present review, we describe its role in skin development, adipogenesis, tooth formation and cranial suture ossification. Experimental data from several studies demonstrate the involvement of Bcl11b in the control of the balance between cell proliferation and differentiation during organ formation and repair, and more specifically in the context of stem cell self-renewal and fate determination. The impact of mutations in the coding sequences of Bcl11b on the development of diseases such as craniosynostosis is also presented. Finally, we discuss genome-wide association studies that suggest a potential influence of single nucleotide polymorphisms found in the 3' regulatory region of Bcl11b on the homeostasis of the cardiovascular system.
Ctip2/Bcl11b是一种具有双重作用（抑制/激活）的锌指转录因子，在各种组织发育过程中，它将表观遗传调控与基因转录联系起来。在健康和病理条件下，它参与多种生理反应。其作用和作用机制在免疫系统和神经系统中得到了最充分的表征。此外，也有报道称它与其他各种组织的发育和稳态有关。在本综述中，我们描述了它在皮肤发育、脂肪生成、牙齿形成和颅缝骨化中的作用。多项研究的实验数据表明，Bcl11b参与了器官形成和修复过程中细胞增殖与分化平衡的控制，特别是在干细胞自我更新和命运决定方面。还介绍了Bcl11b编码序列突变对诸如颅缝早闭等疾病发展的影响。最后，我们讨论了全基因组关联研究，这些研究表明在Bcl11b的3'调控区域发现的单核苷酸多态性对心血管系统稳态可能产生影响。
