Ogg G
MRC Human Immunology Unit, NIHR Biomedical Research Centre Programme, University of Oxford, Weatherall Institute of Molecular Medicine, Oxford, UK.
Clin Exp Allergy. 2009 Mar;39(3):310-6. doi: 10.1111/j.1365-2222.2008.03146.x. Epub 2008 Nov 19.
Our understanding of the pathogenesis of atopic dermatitis has been dramatically enhanced following the identification of the association with loss of function mutations in filaggrin, an epidermal protein thought to be important for cutaneous barrier integrity. However, it has also emerged that Th2 cytokines can influence barrier function, including through modulation of the expression of filaggrin, other structural proteins and peptides important for microbial barrier function. A picture is developing of a complex interplay between epidermal and non-epidermal susceptibilities that contribute to disease. Understanding the key components involved will be important for the identification of new approaches to treatment.
随着与丝聚合蛋白功能缺失突变的关联被发现，我们对特应性皮炎发病机制的理解有了显著提高。丝聚合蛋白是一种对皮肤屏障完整性很重要的表皮蛋白。然而，也有研究表明，Th2细胞因子可影响屏障功能，包括通过调节丝聚合蛋白、其他对微生物屏障功能很重要的结构蛋白和肽的表达来实现。一幅关于导致疾病的表皮和非表皮易感性之间复杂相互作用的图景正在形成。了解其中涉及的关键成分对于确定新的治疗方法至关重要。
