指导胚胎干细胞来源的卵母细胞命运：来自内源性卵子发生的经验教训。
Instructing an embryonic stem cell-derived oocyte fate: lessons from endogenous oogenesis.
作者信息
Nicholas Cory R, Chavez Shawn L, Baker Valerie L, Reijo Pera Renee A
机构信息
Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, California 94304, USA.
出版信息
Endocr Rev. 2009 May;30(3):264-83. doi: 10.1210/er.2008-0034. Epub 2009 Apr 14.
Abstract
Female reproductive potential is limited in the majority of species due to oocyte depletion. Because functional human oocytes are restricted in number and accessibility, a robust system to differentiate oocytes from stem cells would enable a thorough investigation of the genetic, epigenetic, and environmental factors affecting human oocyte development. Also, the differentiation of functional oocytes from stem cells may permit the success of human somatic cell nuclear transfer for reprogramming studies and for the production of patient-specific embryonic stem cells (ESCs). Thus, ESC-derived oocytes could ultimately help to restore fertility in women. Here, we review endogenous and ESC-derived oocyte development, and we discuss the potential and challenges for differentiating functional oocytes from ESCs.
摘要
由于卵母细胞耗竭，大多数物种的雌性生殖潜能是有限的。由于功能性人类卵母细胞的数量和可及性受限，一个强大的将卵母细胞与干细胞进行区分的系统将有助于深入研究影响人类卵母细胞发育的遗传、表观遗传和环境因素。此外，从干细胞分化出功能性卵母细胞可能会使人类体细胞细胞核移植在重编程研究以及生产患者特异性胚胎干细胞（ESC）方面取得成功。因此，ESC来源的卵母细胞最终可能有助于恢复女性的生育能力。在此，我们综述内源性和ESC来源的卵母细胞发育，并讨论从ESC分化出功能性卵母细胞的潜力和挑战。
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本文引用的文献
1
Human oocyte research: the ethics of donation and donor protection.人类卵母细胞研究：捐赠伦理与供者保护
JAMA. 2008 Nov 12;300(18):2174-6. doi: 10.1001/jama.2008.601.
2
Wnt signaling mediates self-organization and axis formation in embryoid bodies.Wnt信号传导介导胚胎体中的自我组织和轴形成。
Cell Stem Cell. 2008 Nov 6;3(5):508-18. doi: 10.1016/j.stem.2008.09.013.
3
Isolation and characterization of pluripotent human spermatogonial stem cell-derived cells.多能性人类精原干细胞衍生细胞的分离与鉴定
Stem Cells. 2009 Jan;27(1):138-49. doi: 10.1634/stemcells.2008-0439.
4
Generation of pluripotent stem cells from adult human testis.从成年人类睾丸中生成多能干细胞。
Nature. 2008 Nov 20;456(7220):344-9. doi: 10.1038/nature07404. Epub 2008 Oct 8.
5
A novel approach for the derivation of putative primordial germ cells and sertoli cells from human embryonic stem cells.一种从人胚胎干细胞中衍生假定原始生殖细胞和支持细胞的新方法。
Stem Cells. 2009 Jan;27(1):68-77. doi: 10.1634/stemcells.2007-1018.
6
Generation of mouse induced pluripotent stem cells without viral vectors.无病毒载体诱导产生小鼠诱导多能干细胞。
Science. 2008 Nov 7;322(5903):949-53. doi: 10.1126/science.1164270. Epub 2008 Oct 9.
7
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Science. 2008 Nov 7;322(5903):945-9. doi: 10.1126/science.1162494. Epub 2008 Sep 25.
8
Isolation of primordial germ cells from differentiating human embryonic stem cells.从分化的人类胚胎干细胞中分离原始生殖细胞。
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Stem Cells. 2008 Nov;26(11):2768-76. doi: 10.1634/stemcells.2008-0124. Epub 2008 Aug 21.
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