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骨关节炎超声检查的系统评价

A systematic review of ultrasonography in osteoarthritis.

作者信息

Keen H I, Wakefield R J, Conaghan P G

机构信息

School of Medicine and Pharmacology, Royal Perth Hospital, Perth, WA, Western Australia.

出版信息

Ann Rheum Dis. 2009 May;68(5):611-9. doi: 10.1136/ard.2008.102434.

Abstract

BACKGROUND

Ultrasonography has been increasingly utilised to aid the understanding and management of rheumatic conditions. In recent years there has been a focus on the validity and utility of ultrasonography in demonstrating joint pathology, although this has largely focused on inflammatory arthritis.

AIMS

To undertake a systematic review of the published literature evaluating ultrasonography as an assessment tool in osteoarthritis.

METHODS

Medline and Pubmed were searched to identify original manuscripts, published before June 2008, utilising ultrasonography to assess the joints of cohorts of subjects with osteoarthritis. Data were extracted from manuscripts meeting the inclusion criteria, with a particular focus on the pathology imaged, the definitions used, scoring systems and their metric properties.

RESULTS

Forty-seven studies were identified that utilised ultrasonography to assess structural pathology in osteoarthritis. Doppler function was only assessed in 10 studies and contrast agents in one. There was heterogeneity with regard to the pathology examined, the definition of pathology, quantification and the reporting of these factors. There was also a lack of construct and criterion validity and data demonstrating reliability and sensitivity to change.

CONCLUSIONS

Whereas there is increasing evidence of the validity of ultrasonography in detecting structural pathology in inflammatory arthritis, more work is required to develop standardised definitions of pathology and to demonstrate the validity of ultrasonography in osteoarthritis.

摘要

背景

超声检查在辅助理解和管理风湿性疾病方面的应用日益广泛。近年来,超声检查在显示关节病变方面的有效性和实用性受到关注,不过这主要集中在炎性关节炎方面。

目的

对已发表的关于评估超声检查作为骨关节炎评估工具的文献进行系统综述。

方法

检索Medline和Pubmed以识别2008年6月之前发表的使用超声检查评估骨关节炎患者队列关节的原始手稿。从符合纳入标准的手稿中提取数据,特别关注成像的病理、使用的定义、评分系统及其度量属性。

结果

共识别出47项使用超声检查评估骨关节炎结构病理的研究。仅10项研究评估了多普勒功能,1项研究评估了造影剂。在所检查的病理、病理定义、量化以及这些因素的报告方面存在异质性。还缺乏结构效度和标准效度,以及证明可靠性和对变化敏感性的数据。

结论

虽然越来越多的证据表明超声检查在检测炎性关节炎结构病理方面具有有效性,但仍需要开展更多工作来制定标准化的病理定义,并证明超声检查在骨关节炎中的有效性。

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