Esmatjes E, Fernández-Cruz L, Ricart M J, Casamitjana R, López-Boado M A, Astudillo E
Endocrinology and Diabetes Unit, University of Barcelona, Spain.
Diabetologia. 1991 Aug;34 Suppl 1:S40-3. doi: 10.1007/BF00587616.
Between January 1983 and June 1990, 32 simultaneous pancreas and kidney transplantations were performed at the University of Barcelona. Insulin-secretion was assessed by intravenous glucose tolerance test performed 24h after transplantation and oral glucose tolerance test during the follow-up. Insulin secretion was also studied in seven non-diabetic patients with kidney transplants. Insulin levels in patients with pancreas and kidney transplantations both at the basal level and after glucose stimulation were higher than normal but not different than those observed in patients with kidney transplantation only. Patients with both pancreas and kidney transplantations and kidney transplantation only presented a mild insulin resistance, measured by the glucose/insulin ratio. Insulin levels during the follow-up of a patient with portal venous drainage were similar to those observed in patients with systemic venous drainage. In conclusion, pancreas transplantation allows a long-term maintenance of glucose homeostasis, although coexisting with an insulin resistance, probably related of the immunosuppressive therapy.
1983年1月至1990年6月期间，巴塞罗那大学进行了32例胰肾联合移植手术。移植后24小时通过静脉葡萄糖耐量试验评估胰岛素分泌情况，并在随访期间进行口服葡萄糖耐量试验。还对7例非糖尿病肾移植患者的胰岛素分泌情况进行了研究。胰肾联合移植患者的基础胰岛素水平和葡萄糖刺激后的胰岛素水平均高于正常水平，但与仅接受肾移植患者的胰岛素水平并无差异。通过葡萄糖/胰岛素比值测量发现，胰肾联合移植患者和仅接受肾移植患者均存在轻度胰岛素抵抗。门静脉引流患者随访期间的胰岛素水平与体静脉引流患者的胰岛素水平相似。总之，胰腺移植可长期维持葡萄糖稳态，尽管同时存在胰岛素抵抗，这可能与免疫抑制治疗有关。
