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作为代谢综合征治疗靶点的脂肪组织炎症成分

Inflammatory components of adipose tissue as target for treatment of metabolic syndrome.

作者信息

Yu Rina, Kim Chu-Sook, Kang Ji-Hye

出版信息

Forum Nutr. 2009;61:95-103. doi: 10.1159/000212742. Epub 2009 Apr 7.

Abstract

Obesity is an independent risk factor in the etiology of various metabolic diseases such as insulin resistance, type 2 diabetes and cardiovascular diseases. In this chapter, we discuss obesity-induced inflammation as a potential link with obesity-related metabolic syndrome, and discuss how obesity-related inflammatory components such as immune cells, and cytokines/chemokines and adipocy-tokines, provoke obesity-related pathologies. In particular, we focus on the hypothesis that anti-inflammatory food factors/phytochemicals may be useful for inhibiting the initiation and development of obesity-induced inflammation and metabolic syndrome.

摘要

肥胖是多种代谢性疾病病因中的独立危险因素,如胰岛素抵抗、2型糖尿病和心血管疾病。在本章中,我们讨论肥胖诱导的炎症作为与肥胖相关代谢综合征的潜在联系,并讨论肥胖相关的炎症成分,如免疫细胞、细胞因子/趋化因子和脂肪细胞因子,如何引发肥胖相关的病理变化。特别是,我们关注这样一种假说,即抗炎食物因子/植物化学物质可能有助于抑制肥胖诱导的炎症和代谢综合征的发生和发展。

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