Studahl Marie, Günther Göran, Rosengren Lars
Dept. of Infectious Diseases, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
J Neurol. 2009 Apr;256(4):586-90. doi: 10.1007/s00415-009-0124-y. Epub 2009 Apr 9.
This study was mainly aimed at the comparative analysis of serum S-100B protein in patients with herpes simplex encephalitis (HSE) and tick-borne encephalitis (TBE). S-100B protein is an established biochemical marker of astroglial damage in central nervous system (CNS) injury.
Serum levels of S-100B were measured using a commercial immunolumino-metric assay (LIA).
Patients with HSE (n = 17) had significantly higher levels of S-100B with median 0.351 microg/l (range 0.017-0.636) compared to patients with TBE (n = 15), who had 0.04 microg/l (range 0.001-0.542) (p < 0.001), as well as controls (n = 17) 0.054 (range 0.004-0.214) (p < 0.001). 11/17 patients with HSE had serum S-100B levels above 0.2 microg/l, in contrast to 1/15 patients with TBE and 1/17 of the control patients. The patients with HSE with serum levels below 0.2 microg/l had a mean 3.2 days disease duration, while patients with levels above 0.2 microg/l had 6 days disease duration.
The serum levels of S-100B in the acute stage of disease were significantly higher in patients with HSE than in patients with TBE or controls. A role for the use of serum S-100B in monitoring CNS damage during initial stage of disease in HSE is suggested.
本研究主要旨在对单纯疱疹病毒性脑炎（HSE）和蜱传脑炎（TBE）患者的血清S - 100B蛋白进行对比分析。S - 100B蛋白是中枢神经系统（CNS）损伤中星形胶质细胞损伤的一种既定生化标志物。
采用商业化免疫发光分析法（LIA）测定血清S - 100B水平。
HSE患者（n = 17）的S - 100B水平显著高于TBE患者（n = 15），HSE患者S - 100B水平中位数为0.351微克/升（范围0.017 - 0.636），而TBE患者为0.04微克/升（范围为0.001 - 0.542）（p < 0.001），对照组（n = 17）为0.054（范围0.004 - 0.214）（p < 0.001）。17例HSE患者中有11例血清S - 100B水平高于0.2微克/升，相比之下，TBE患者中有1例以及对照患者中有1例高于此水平。血清水平低于0.2微克/升的HSE患者疾病持续时间平均为3.2天，而水平高于0.2微克/升的患者疾病持续时间为6天。
HSE患者疾病急性期的血清S - 100B水平显著高于TBE患者或对照组。提示血清S - 100B在监测HSE疾病初始阶段的CNS损伤中具有一定作用。
