Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Harbin, People's Republic of China.
Acta Diabetol. 2009 Dec;46(4):339-43. doi: 10.1007/s00592-009-0118-3. Epub 2009 Apr 15.
The aim of this meta-analysis was to determine the nature of the association between TNF 238 G/A polymorphism and the risk for T2D. We searched databases updated on January 2009 for all publications on the association between this variation and T2D. Data on genotypes and the numbers of cases and controls were assessed using Review Manager 4.2. Meta-analysis of the overall and specific populations was conducted, and odds ratios (OR) and 95% confidence intervals (95% CI) were calculated in the fixed-effect model. I(2) statistic was calculated to examine heterogeneity, and publication bias was evaluated by Egger test. The overall OR (95% CI) for AA and GA genotypes versus GG genotype for TNF-alpha-238 was 1.15 (0.92-1.44), which in European and Asian populations were 1.18 (0.92-1.51) and 1.13 (0.62-2.04), respectively. This first meta-analysis of data from the current and published studies did not detect any association between the polymorphism of TNF 238 G/A and risk for T2D.
本荟萃分析旨在确定 TNF238G/A 多态性与 T2D 风险之间的关联性质。我们检索了截至 2009 年 1 月更新的数据库，以查找关于该变异与 T2D 之间关联的所有出版物。使用 Review Manager 4.2 评估基因型以及病例和对照的数量的数据。在固定效应模型中进行了总体和特定人群的荟萃分析，并计算了比值比（OR）和 95%置信区间（95%CI）。I(2)统计量用于检验异质性，并通过 Egger 检验评估发表偏倚。TNF-α-238 的 AA 和 GA 基因型与 GG 基因型的总体 OR（95%CI）分别为 1.15（0.92-1.44），在欧洲和亚洲人群中分别为 1.18（0.92-1.51）和 1.13（0.62-2.04）。这是对当前和已发表研究数据进行的首次荟萃分析，并未发现 TNF238G/A 多态性与 T2D 风险之间存在任何关联。
