TNF308G/A 多态性与 2 型糖尿病的荟萃分析。
Meta-analysis of TNF 308 G/A polymorphism and type 2 diabetes mellitus.
机构信息
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
出版信息
PLoS One. 2011 Apr 8;6(4):e18480. doi: 10.1371/journal.pone.0018480.
BACKGROUND AND OBJECTIVES
Many investigations have focused the association between TNF 308 G/A polymorphism and risk for type 2 diabetes mellitus (T2DM). However, the sample sizes of most of the studies were small. The aim of this study is to evaluate the precise association between this variant and risk for T2DM in a large-scale meta-analysis.
METHODS
All publications were searched on the association between TNF 308 G/A polymorphism and T2DM. The key words were as follows: diabetes, tumor necrosis factor and polymorphism/variant/genotype. This meta-analysis was assessed by Review manager 5.0.
RESULTS
There were 18 studies identified. The odds ratios (ORs) and 95% confidence intervals (CI) for GA+AA versus GG genotype of TNF 308 G/A polymorphism were 1.03 (0.95-1.12), 1.03 (0.94-1.13) and 1.03 (0.78-1.36) in overall, Caucasian and Asian populations, respectively. The sensitivity analysis further strengthened the validity of this association. No publication bias or heterogeneity was observed in this study.
CONCLUSION
In summary, there was no significant association detected between the TNF 308 G/A polymorphism and risk for T2DM.
背景与目的
许多研究都集中在 TNF308G/A 多态性与 2 型糖尿病（T2DM）风险之间的关联上。然而，大多数研究的样本量都很小。本研究旨在通过大规模荟萃分析评估该变体与 T2DM 风险之间的确切关联。
方法
在关联 TNF308G/A 多态性与 T2DM 的基础上，对所有出版物进行了搜索。关键词如下：糖尿病、肿瘤坏死因子和多态性/变体/基因型。该荟萃分析采用 Review manager5.0 进行评估。
结果
确定了 18 项研究。TNF308G/A 多态性的 GA+AA 与 GG 基因型的比值比（OR）和 95%置信区间（CI）分别为 1.03（0.95-1.12）、1.03（0.94-1.13）和 1.03（0.78-1.36），总体而言、白种人和亚洲人群中。敏感性分析进一步加强了这种关联的有效性。在这项研究中没有观察到发表偏倚或异质性。
结论
综上所述，TNF308G/A 多态性与 T2DM 风险之间没有显著关联。
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