Plant Resources Research Institute, Duksung Women's University, Seoul 132-714, Korea.
Phytother Res. 2009 Dec;23(12):1748-53. doi: 10.1002/ptr.2840.
The effects of Poncirus trifoliata (P. trifoliata) (Ponciri Fructus, PF) extract and its constituents such as neohesperidin and poncirin on gastritis in rats and human gastric cancer cells were investigated. The PF 70% ethanol extracts (1 g) showed approximately 11.38% of acid-neutralizing capacities and cytotoxicity (IC50=85.39 microg/mL) against human AGS gastric cancer cells. In addition, neohesperidin exhibited antioxidant activity (IC50=22.31 microg/mL) in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. Neohesperidin (50 mg/kg) and poncirin (100 mg/kg) significantly inhibited 55.0% and 60.0% of HCl/ethanol-induced gastric lesions, respectively, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. From these results, it could be suggested that neohesperidin and poncirin isolated from PF may be useful for the treatment and/or protection of gastritis.
研究了枳实（Poncirus trifoliata）（枳实，PF）提取物及其成分如新橙皮苷和蓬皮苷对大鼠胃炎和人胃癌细胞的影响。PF 70%乙醇提取物（1 g）对人 AGS 胃癌细胞的酸中和能力和细胞毒性（IC50=85.39μg/mL）分别约为 11.38%。此外，新橙皮苷在 1,1-二苯基-2-苦基肼（DPPH）自由基清除测定中表现出抗氧化活性（IC50=22.31μg/mL）。新橙皮苷（50 mg/kg）和蓬皮苷（100 mg/kg）分别显著抑制 55.0%和 60.0%的 HCl/乙醇诱导的胃损伤，同时增加了黏液含量。在幽门结扎大鼠中，新橙皮苷（50 mg/kg）显著减少了胃分泌量和胃酸分泌量，并增加了 pH 值。从这些结果可以看出，从 PF 中分离出的新橙皮苷和蓬皮苷可能对胃炎的治疗和/或保护有用。
