Yun Kyung Eun, Kim Seon Mee, Choi Kyung Mook, Park Hye Soon
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Metabolism. 2009 Jun;58(6):798-802. doi: 10.1016/j.metabol.2009.01.017.
Adipocyte fatty acid-binding protein (A-FABP) is a newly recognized adipokine that plays a role in the development of obesity and insulin resistance in adults. We investigated the association between A-FABP levels and obesity and insulin resistance in school-aged children. One hundred sixty-one 9-year-old Korean children (80 boys and 81 girls) voluntarily participated in this study at school-based health examinations. Weight, height, waist circumference, and blood pressure were measured. Fasting plasma glucose, triglycerides, high-density lipoprotein cholesterol, insulin, and A-FABP levels were measured; and insulin resistance was estimated by the homeostasis model assessment. Subjects with higher body mass index (BMI) percentiles had correspondingly higher concentrations of A-FABP in both boys and girls. Subjects within the highest quartile of A-FABP levels had correspondingly poor metabolic risk profiles (BMI, waist circumference, triglycerides, high-density lipoprotein cholesterol, fasting insulin, and homeostasis model assessment of insulin resistance) compared with those in the lowest A-FABP quartile (P < .01). Serum A-FABP concentrations were significantly correlated with BMI (r = 0.58, P < .01) and waist circumference (r = 0.51, P < .01). However, the significant correlation between serum A-FABP and insulin resistance faded after adjustment for BMI. Adipocyte fatty acid-binding protein was closely associated with obesity or abdominal obesity in children; however, the independent relationship between A-FABP and insulin resistance in children is still unclear and remains to be determined.
脂肪细胞脂肪酸结合蛋白（A-FABP）是一种新发现的脂肪因子，在成人肥胖和胰岛素抵抗的发展中起作用。我们调查了学龄儿童A-FABP水平与肥胖及胰岛素抵抗之间的关联。161名9岁韩国儿童（80名男孩和81名女孩）在学校健康检查中自愿参与了本研究。测量了体重、身高、腰围和血压。检测了空腹血糖、甘油三酯、高密度脂蛋白胆固醇、胰岛素和A-FABP水平；并通过稳态模型评估来估计胰岛素抵抗。体重指数（BMI）百分位数较高的受试者，无论男孩还是女孩，其A-FABP浓度相应更高。与A-FABP水平最低四分位数的受试者相比，A-FABP水平最高四分位数的受试者代谢风险状况相应较差（BMI、腰围、甘油三酯、高密度脂蛋白胆固醇、空腹胰岛素和胰岛素抵抗稳态模型评估）（P <.01）。血清A-FABP浓度与BMI（r = 0.58，P <.01）和腰围（r = 0.51，P <.01）显著相关。然而，在调整BMI后，血清A-FABP与胰岛素抵抗之间的显著相关性消失。脂肪细胞脂肪酸结合蛋白与儿童肥胖或腹型肥胖密切相关；然而，A-FABP与儿童胰岛素抵抗之间的独立关系仍不清楚，有待确定。
