血清脂肪细胞脂肪酸结合蛋白、视黄醇结合蛋白 4 和脂联素浓度与韩国男孩代谢综合征发展的关系：一项为期 3 年的前瞻性队列研究。
Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys: a 3-y prospective cohort study.
机构信息
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.
出版信息
Am J Clin Nutr. 2011 Jan;93(1):19-26. doi: 10.3945/ajcn.2010.29667. Epub 2010 Nov 24.
BACKGROUND
Adipocyte fatty acid-binding protein (A-FABP), retinol-binding protein 4 (RBP4), and adiponectin have been associated with insulin resistance and the metabolic syndrome in adults.
OBJECTIVE
We evaluated the association of A-FABP, RBP4, and adiponectin with the metabolic syndrome in Korean boys.
DESIGN
In this prospective cohort study, 159 boys participated in a school-based health examination and were followed up after 3 y. The metabolic syndrome in children was defined by using the pediatric adaptation of the National Cholesterol Education Program criteria.
RESULTS
Compared with normal-weight participants, overweight children had significantly higher A-FABP (23.6 ± 8.2 compared with 12.8 ± 5.1 μg/L, P < 0.001) and RBP4 (69.3 ± 17.1 compared with 59.7 ± 15.3 μg/mL, P = 0.001) concentrations and significantly lower adiponectin concentrations (11.5 ± 5.4 compared with 18.1 ± 8.4 μg/mL, P < 0.001). Baseline A-FABP concentrations were significantly higher in children who developed the metabolic syndrome than in those who did not, whereas adiponectin concentrations were significantly lower. Baseline RBP4 concentrations were not significantly different between the 2 groups. Multiple logistic regression analysis showed that only A-FABP was an independent predictor of the development of the metabolic syndrome after adjustment for Tanner stage, insulin resistance, body mass index, sleep duration, and physical activity (odds ratio: 17.3; 95% CI: 1.25, 239.76; highest compared with lowest tertile), whereas the significant association between adiponectin and the metabolic syndrome observed by using bivariate analysis reflects, in part, an underlying association with obesity.
CONCLUSION
A-FABP predicts the development of the metabolic syndrome independently of pubertal status, adiposity, and insulin resistance in Korean boys.
背景
脂肪细胞脂肪酸结合蛋白（A-FABP）、视黄醇结合蛋白 4（RBP4）和脂联素与成年人的胰岛素抵抗和代谢综合征有关。
目的
我们评估了 A-FABP、RBP4 和脂联素与韩国男孩代谢综合征的关系。
设计
在这项前瞻性队列研究中，159 名男孩参加了一项基于学校的健康检查，并在 3 年后进行了随访。儿童代谢综合征采用国家胆固醇教育计划标准的儿科适应性定义。
结果
与正常体重参与者相比，超重儿童的 A-FABP（23.6 ± 8.2 与 12.8 ± 5.1 μg/L，P < 0.001）和 RBP4（69.3 ± 17.1 与 59.7 ± 15.3 μg/mL，P = 0.001）浓度明显更高，脂联素浓度明显更低（11.5 ± 5.4 与 18.1 ± 8.4 μg/mL，P < 0.001）。与未发生代谢综合征的儿童相比，基线时 A-FABP 浓度较高的儿童发生代谢综合征的可能性明显更高，而脂联素浓度较低。两组间基线 RBP4 浓度无显著差异。多因素逻辑回归分析显示，仅 A-FABP 是调整了青春期阶段、胰岛素抵抗、体重指数、睡眠时间和体力活动后代谢综合征发生的独立预测因子（比值比：17.3；95%CI：1.25，239.76；最高与最低三分位），而使用双变量分析观察到脂联素与代谢综合征之间的显著关联部分反映了与肥胖的潜在关联。
结论
A-FABP 可独立于青春期状态、肥胖和胰岛素抵抗预测韩国男孩代谢综合征的发生。
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