College of Chemistry and Chemical Engineering and State Key Laboratory of Applied, Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
J Fluoresc. 2009 Sep;19(5):847-56. doi: 10.1007/s10895-009-0482-y. Epub 2009 Apr 16.
A novel 6-ethoxy chromone-3-carbaldehyde benzoyl hydrazone (L) and its Ln(III) complexes, [Ln = Sm (1), Eu (2), Gd (3), Tb (4)], have been synthesized and characterized. The fluorescence properties of the Eu(III) and Sm(III) complexes in solid state and Eu(III) complex in different solutions (DMF, DMSO, methanol and acetonitrile) were investigated. At the same time, the DNA-binding properties of the two complexes are investigated using UV-Vis absorption spectroscopy, fluorescence spectroscopy, viscosity measurement. All the experimental evidences indicate that the two complexes can bind to CT-DNA via an intercalation mechanism. Furthermore, antioxidant activity tests in vitro showed that the complexes have significant antioxidative activity against hydroxyl free radicals from the Fenton reaction.
一种新型的 6-乙氧基色酮-3-醛苯甲酰腙（L）及其 Ln（III）配合物[Ln = Sm（1），Eu（2），Gd（3），Tb（4）]已经被合成并进行了表征。研究了 Eu（III）和 Sm（III）配合物在固态和 Eu（III）配合物在不同溶液（DMF、DMSO、甲醇和乙腈）中的荧光性质。同时，利用紫外可见吸收光谱、荧光光谱和粘度测量法研究了两个配合物的 DNA 结合性质。所有的实验证据表明，这两个配合物可以通过嵌入机制与 CT-DNA 结合。此外，体外抗氧化活性测试表明，配合物对 Fenton 反应产生的羟基自由基具有显著的抗氧化活性。
