Yamaoka K, Edamatsu R, Mori A
Department of Neurochemistry, Okayama University Medical School, Japan.
Free Radic Biol Med. 1991;11(3):299-306. doi: 10.1016/0891-5849(91)90127-o.
After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p less than 0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.
单次暴露于0.05至0.50戈瑞的剂量后，全身X射线照射4小时后，受辐照大鼠免疫器官中的超氧化物歧化酶（SOD）活性与对照组相比显著增加了50%至90%（以下p<0.05）。对于0.50至2.50戈瑞的剂量，大脑和肝脏中的剂量有增加30%至50%的趋势。对于0.10至1.00戈瑞的剂量，免疫器官中的硫代巴比妥酸反应物（TBARS，脂质过氧化物）水平与对照组相比显著降低了20%至50%。在接近0.50戈瑞的剂量下，大脑和肝脏中观察到降低了20%至30%。当剂量为0.25戈瑞时，脾脏中的SOD活性显示出辐射诱导的持续增加至少12周，肝脏中持续增加8周，大脑和胸腺中持续增加4周，骨髓中持续增加约1周。大脑和胸腺中的TBARS水平因辐射而持续降低至少12周，骨髓中的TBARS水平持续降低8小时。
