Sakuraba H, Tanaka H
Brain Dev. 1983;5(5):457-63. doi: 10.1016/s0387-7604(83)80074-6.
Wistar rats were X-irradiated in utero and biochemical analysis of the cerebrum was performed on gestational day (g d) 21. The cerebral weight was significantly lower in the irradiated group on g d 13 with above 75R than in the control group. The contents of DNA, RNA and protein were decreased in the cerebrum of the fetuses irradiated with 100R on g d 13 when calculated per cerebrum, and DNA only was decreased occasionally when expressed as per gm wet weight. The lipid peroxide level of the cerebrum in the irradiated group was increased compared to that of the control group. The superoxide dismutase (SOD; E.C. 1.15.1.1.) activity was extremely low and lipid peroxidation in vitro was considerably enhanced in fetal cerebrum. The low activity of SOD may be one of the factors which cause the vulnerability of fetal brain to irradiation.
对孕期的Wistar大鼠进行子宫内X射线照射，并在妊娠第21天对大脑进行生化分析。在妊娠第13天，接受75R以上照射的实验组大鼠脑重量显著低于对照组。妊娠第13天接受100R照射的胎儿大脑中，按全脑计算，DNA、RNA和蛋白质含量下降；按每克湿重计算，仅DNA偶尔下降。与对照组相比，照射组胎儿大脑的脂质过氧化物水平升高。超氧化物歧化酶（SOD；E.C. 1.15.1.1.）活性极低，且胎儿大脑的体外脂质过氧化作用显著增强。SOD活性低可能是导致胎儿大脑对辐射敏感的因素之一。
