慢性肾脏病矿物质与骨异常中血管钙化的发病机制：骨骼与血管系统之间的联系
The pathogenesis of vascular calcification in the chronic kidney disease mineral bone disorder: the links between bone and the vasculature.
作者信息
Hruska Keith A, Mathew Suresh, Lund Richard J, Memon Imran, Saab Georges
机构信息
Department of Pediatrics, Division of Nephrology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Semin Nephrol. 2009 Mar;29(2):156-65. doi: 10.1016/j.semnephrol.2009.01.008.
Abstract
Considerable scientific progress in the pathogenesis of vascular calcification that has accrued in recent years is reviewed in this article. Factors regulating mesenchymal cell differentiation and their role in the neointimal calcification of atherosclerosis and the vascular media calcification observed in chronic kidney disease and diabetes are discussed, as is the role of bone regulatory proteins in bone mineralization and vascular calcification. This includes recent studies related to fetuin-A, and the discovery of a new circulating hormone involved in regulating phosphate homeostasis and sensing skeletal hydroxyapatite precipitation. Finally, the relationship between skeletal mineralization and vascular mineralization is discussed in terms of their links, especially through serum phosphate concentrations.
摘要
本文综述了近年来在血管钙化发病机制方面取得的重大科学进展。讨论了调节间充质细胞分化的因素及其在动脉粥样硬化新内膜钙化以及慢性肾病和糖尿病中观察到的血管中层钙化中的作用，还讨论了骨调节蛋白在骨矿化和血管钙化中的作用。这包括与胎球蛋白-A相关的最新研究，以及一种参与调节磷酸盐稳态和感知骨骼羟基磷灰石沉淀的新循环激素的发现。最后，从骨骼矿化和血管矿化的联系，特别是通过血清磷酸盐浓度的联系方面，讨论了它们之间的关系。
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