老年人血清抵抗素浓度与新发心力衰竭风险：健康、衰老与身体成分（Health ABC）研究
Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study.
作者信息
Butler Javed, Kalogeropoulos Andreas, Georgiopoulou Vasiliki, de Rekeneire Nathalie, Rodondi Nicolas, Smith Andrew L, Hoffmann Udo, Kanaya Alka, Newman Anne B, Kritchevsky Stephen B, Vasan Ramachandran S, Wilson Peter W F, Harris Tamara B
机构信息
Emory University, Atlanta Ga., USA.
出版信息
Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1144-9. doi: 10.1161/ATVBAHA.109.186783. Epub 2009 Apr 16.
OBJECTIVE
Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans.
METHODS AND RESULTS
We studied 2902 older persons without prevalent HF (age, 73.6+/-2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3+/-10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction.
CONCLUSIONS
Serum resistin concentrations are independently associated with risk for incident HF in older persons.
目的
抵抗素与炎症和胰岛素抵抗相关，并对心肌细胞产生直接影响，包括心肌肥大和收缩改变。我们研究了人类血清抵抗素浓度与发生心力衰竭（HF）风险之间的关联。
方法与结果
我们对参加健康、衰老和身体成分（Health ABC）研究的2902名无HF病史的老年人进行了研究（年龄73.6±2.9岁；男性占48.1%；白人占58.8%）。基线血清抵抗素浓度（20.3±10.0 ng/mL）与临床变量、生化指标、炎症和胰岛素抵抗标志物、脂肪细胞因子及肥胖指标之间的相关性较弱（所有rho<0.25）。在中位随访9.4年期间，341名参与者（11.8%）发生了HF。在控制临床变量、生物标志物和肥胖指标的Cox比例风险模型中，抵抗素与发生HF的风险密切相关（校正模型中每10.0 ng/mL的HR为1.15；95%CI为1.05至1.27；P=0.003）。在性别、种族、糖尿病以及冠心病现患和新发亚组中的结果具有可比性。在HF诊断时可获得左心室射血分数的参与者中（341名中的265名；77.7%），抵抗素与HF风险的关联在射血分数降低与保留的病例中具有可比性。
结论
血清抵抗素浓度与老年人发生HF的风险独立相关。
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