Patel Jatin, Iyer Abishek, Brown Lindsay
School of Biomedical Sciences, The University of Queensland, 4072, Australia.
Indian J Biochem Biophys. 2009 Feb;46(1):66-72.
The increasing prevalence of type 2 diabetes is associated with increasing health costs, especially for the treatment of cardiovascular disease. The development of new treatment modalities requires animal models that mimic the range of pathophysiological changes seen in diabetic humans. Dietary fructose intake has been linked to the increase in insulin resistance as part of the metabolic syndrome; fructose-fed rats develop type 2 diabetes. This study has characterized the cardiovascular changes in young adult male Wistar rats fed a 61% fructose diet for 16 weeks. Our results extend the reported changes of hypertension, lipid abnormalities, impaired glucose tolerance and impaired oxidative defense to include ventricular dilatation with hypertrophy and decreased contractile function, together with increased inflammatory cell infiltration into the ventricular myocardium, resulting in excessive collagen deposition and an increased stiffness of the left ventricle. However, endothelial dysfunction, tactile allodynia as a symptom of peripheral neuropathy and retinopathy are not present in these rats, in contrast to the streptozotocin-induced model of type 1 diabetes. Thus, fructose feeding mimics many, but not all, of the symptoms of type 2 diabetes in humans.
2型糖尿病患病率的不断上升与医疗成本的增加相关，尤其是心血管疾病的治疗成本。新治疗方法的开发需要能够模拟糖尿病患者所出现的一系列病理生理变化的动物模型。饮食中果糖的摄入与作为代谢综合征一部分的胰岛素抵抗增加有关；喂食果糖的大鼠会患上2型糖尿病。本研究对喂食61%果糖饮食16周的年轻成年雄性Wistar大鼠的心血管变化进行了表征。我们的结果扩展了已报道的高血压、脂质异常、糖耐量受损和氧化防御受损等变化，还包括心室扩张伴肥厚以及收缩功能下降，同时炎症细胞浸润心室心肌增加，导致胶原过度沉积和左心室僵硬度增加。然而，与链脲佐菌素诱导的1型糖尿病模型不同，这些大鼠不存在内皮功能障碍、作为周围神经病变症状的触觉异常性疼痛和视网膜病变。因此，喂食果糖模拟了人类2型糖尿病的许多但并非所有症状。
