Joshi Priyanka, Joshi Sushil, Semwal Deepak Kumar, Verma Kanika, Dwivedi Jaya, Sharma Swapnil
Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, India.
R&D, Patanjali Ayurved Ltd, Patanjali Food and Herbal Park, Haridwar, Uttarakhand, India.
Mol Cell Biochem. 2022 Oct;477(10):2359-2385. doi: 10.1007/s11010-022-04447-8. Epub 2022 May 15.
Curcumin, belongs to the curcuminoid family, is a natural phenolic compound, presenting low bioavailability and pleiotropic activity. Since ancient times, curcumin has been in use as food spices and folk remedy to treat cough, cold, cuts and wounds, and skin diseases. Preclinical and clinical studies have indicated that curcumin acts a promising therapeutic agent in the management of a wide array of health issues, viz., hyperlipidemia, metabolic syndrome, anxiety, arthritis, cancer and inflammatory diseases. Owing to its enormous potential, recent research has been focused on the synthesis of curcumin and its analogues for the management of metabolic disorders. In the current scenario, hypertension is considered as a key risk factor due to its involvement in various pathogeneses. Mechanistically, curcumin and its analogues like hexahydrocurcumin, tetrahydrocurcumin, etc. have been reported to elicit anti-hypertensive effect through diverse signalling pathways, viz., pathway mediated by Nrf2-ARE, NF-kB, NO/cGMP/PDE5/MMPs, RAAS/ACE, HAT/HDAC, G0/G1/apoptosis, CYP3A4, UCP2/PARP, VEGF/STAT/AXL/tyrosine kinase and TGF-β/Smad-mediated pathways. Thus, the present review has been aimed to highlight different molecular pathways involved in the amelioration of hypertension and associated conditions.
姜黄素属于姜黄素类化合物，是一种天然酚类化合物，具有低生物利用度和多效活性。自古以来，姜黄素就被用作食品香料和民间药物，用于治疗咳嗽、感冒、割伤和伤口以及皮肤病。临床前和临床研究表明，姜黄素在管理一系列健康问题方面是一种有前景的治疗剂，即高脂血症、代谢综合征、焦虑症、关节炎、癌症和炎症性疾病。由于其巨大的潜力，最近的研究集中在姜黄素及其类似物的合成上，用于管理代谢紊乱。在当前情况下，高血压因其参与各种发病机制而被视为关键危险因素。从机制上讲，据报道姜黄素及其类似物如六氢姜黄素、四氢姜黄素等通过多种信号通路发挥抗高血压作用，即由Nrf2-ARE、NF-κB、NO/cGMP/PDE5/MMPs、RAAS/ACE、HAT/HDAC、G0/G1/凋亡、CYP3A4、UCP2/PARP、VEGF/STAT/AXL/酪氨酸激酶和TGF-β/Smad介导的通路。因此，本综述旨在强调参与改善高血压及相关病症的不同分子途径。
