碘催化合成吡喃并喹啉、硫代吡喃并喹啉、噻吩并喹啉和萘并[2,7]萘啶衍生物的高效方法。

Efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives catalyzed by iodine.

作者信息

Wang Xiang-Shan, Li Qing, Wu Jian-Rong, Tu Shu-Jiang

机构信息

School of Chemistry and Chemical Engineering, Xuzhou Normal University, The Key Laboratory of Biotechnology on Medical Plant, Xuzhou Jiangsu 221116, PR China.

出版信息

J Comb Chem. 2009 May-Jun;11(3):433-7. doi: 10.1021/cc900026x.

DOI:10.1021/cc900026x

PMID:19374375

Abstract

A mild and efficient method for the synthesis of pyranoquinoline, thiopyranoquinoline, thienoquinoline, and naphtho[2,7]naphthyridine derivatives via three-component reaction of aromatic aldehyde, naphthalen-2-amine, and heterocycloketones, including tetrahydropyran-4-one, tetrahydrothiopyran-4-one, pyridinone, and thiophenone, is described using iodine as catalyst. The features of this procedure are mild reaction conditions, good to high yields, and operational simplicity.

摘要

描述了一种温和且高效的方法，以碘为催化剂，通过芳族醛、萘-2-胺和杂环酮（包括四氢吡喃-4-酮、四氢噻喃-4-酮、吡啶酮和苯乙酮）的三组分反应合成吡喃并喹啉、硫代吡喃并喹啉、噻吩并喹啉和萘并[2,7]萘啶衍生物。该方法的特点是反应条件温和、产率良好至高、操作简单。