Wang Xiang-Shan, Yang Ke, Zhou Jie, Tu Shu-Jiang
School of Chemistry and Chemical Engineering, Xuzhou Normal University, The Key Laboratory of Biotechnology on Medical Plant, Xuzhou Jiangsu, PR China.
J Comb Chem. 2010 Jul 12;12(4):417-21. doi: 10.1021/cc900174p.
A mild and facile method for the combinatorial synthesis of quinazolin-4-(1H)-one derivatives, containing simple 2,2-disubstituted quinazolin-4-(1H)-ones, spirocyclic quinazolin-4-(1H)-ones, spiro-heterocyclic quinazolin-4-(1H)-ones, and dispirocyclic quinazolin-4-(1H)-ones, is described, which results in high yields by using ionic liquids as green media. The method involves the reaction of 2-aminobenzamides with various ketones catalyzed by iodine and provides new quinazolin-4-(1H)-one library for biomedical screening.
本文描述了一种温和且简便的方法，用于组合合成喹唑啉-4-(1H)-酮衍生物，包括简单的2,2-二取代喹唑啉-4-(1H)-酮、螺环喹唑啉-4-(1H)-酮、螺杂环喹唑啉-4-(1H)-酮和双螺环喹唑啉-4-(1H)-酮。该方法以离子液体作为绿色介质，产率较高。该方法涉及在碘催化下2-氨基苯甲酰胺与各种酮的反应，并为生物医学筛选提供了新的喹唑啉-4-(1H)-酮文库。
