Han Zheng-Guo, Miao Chun-Bao, Shi Feng, Ma Ning, Zhang Ge, Tu Shu-Jiang
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu, PR China.
J Comb Chem. 2010 Jan-Feb;12(1):16-9. doi: 10.1021/cc900030e.
A sequential three-component reaction of 3,5-diarylidenepiperidin-4-one, malononitrile, and amine (such as aromatic amine, cyclopropanamine, and NH(4)OAc) in acetic acid under microwave irradiation has been developed. In this one-pot reaction, a series of new N-substituted 2-amino-1,6-naphthyridine derivatives were synthesized with excellent yields. This method has the advantages of operational simplicity and increased safety for small-scale fast synthesis of N-aryl 2-amino-1,6-naphthyridines for biomedical screening.
在微波辐射下，3,5 - 二芳亚甲基哌啶 - 4 - 酮、丙二腈和胺（如芳香胺、环丙胺和醋酸铵）在乙酸中发生了连续的三组分反应。在这个一锅法反应中，一系列新型的N - 取代2 - 氨基 - 1,6 - 萘啶衍生物以优异的产率被合成出来。该方法具有操作简单的优点，并且在用于生物医学筛选的N - 芳基2 - 氨基 - 1,6 - 萘啶的小规模快速合成中安全性更高。
