Haginoya Kazuhiro, Noguchi Rie, Zhao Yajuan, Munakata Mitsutoshi, Yokoyama Hiroyuki, Tanaka Soichiro, Hino-Fukuyo Naomi, Uematsu Mitsugu, Yamamoto Katsuya, Takayanagi Masaru, Iinuma Kazuie, Tsuchiya Shigeru
Department of Pediatrics, Tohoku University School of Medicine, Sendai 980-8574, Japan.
Epilepsy Res. 2009 Aug;85(2-3):314-7. doi: 10.1016/j.eplepsyres.2009.03.013. Epub 2009 Apr 16.
We measured the levels of pro- and anti-inflammatory cytokines in the cerebrospinal fluid (CSF) of 24 patients with West syndrome to clarify whether inflammatory cytokines were involved in the pathophysiology of West syndrome. There was no significant elevation of any of the three pro-inflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, in patients with West syndrome as compared with those in controls. However, level of anti-inflammatory cytokine, IL-1 receptor antagonist was significantly decreased in the CSF of patients with West syndrome. Further study is needed to elucidate whether an immune system disturbance is involved in the pathophysiology of West syndrome.
我们检测了24例韦斯特综合征患者脑脊液（CSF）中促炎和抗炎细胞因子的水平，以阐明炎性细胞因子是否参与了韦斯特综合征的病理生理过程。与对照组相比，韦斯特综合征患者的三种促炎细胞因子，即白细胞介素（IL）-1β、IL-6和肿瘤坏死因子-α，均无显著升高。然而，抗炎细胞因子IL-1受体拮抗剂的水平在韦斯特综合征患者的脑脊液中显著降低。需要进一步研究以阐明免疫系统紊乱是否参与了韦斯特综合征的病理生理过程。
