Cobo Teresa, Palacio Montse, Navarro-Sastre Aleix, Ribes Antonia, Bosch Jordi, Filella Xavier, Gratacós Eduard
Department of Maternal-Fetal Medicine, Institut de Investigacions Biomèdiques August Pi-Sunyer, Hospital Clínic, University of Barcelona, Barcelona, Spain.
Am J Obstet Gynecol. 2009 May;200(5):499.e1-6. doi: 10.1016/j.ajog.2008.12.036.
To assess proteomic biomarkers and interleukin-6 alone or in combination to predict intraamniotic infection, preterm birth, and neonatal morbidity in preterm labor with intact membranes.
Amniotic fluid interleukin-6 and selected proteomic biomarkers were assayed from 86 patients with preterm labor and intact membranes (22-36 weeks). The predictive value of each marker alone or in combination was evaluated for intraamniotic infection, preterm birth, and neonatal composite morbidity.
Both interleukin-6 (odds ratio, 19.5; P = .012) and proteomic biomarkers (odds ratio, 25.2; P = .001) were statistically independent predictors of intraamniotic infection with sensitivity, positive predictive value, and false-positive rates of 25%, 17.6%, and 20% when 1 marker was present and of 75%, 75%, and 4.3% when both were detected. Their combination did not improve prediction of preterm birth or neonatal morbidity.
The combined use of proteomic biomarkers and interleukin-6 to predict intraamniotic infection shows better accuracy than when used alone.
评估蛋白质组学生物标志物和白细胞介素-6单独或联合使用时，对胎膜完整的早产患者羊膜腔内感染、早产及新生儿发病情况的预测价值。
对86例胎膜完整的早产患者（孕周22 - 36周）的羊水白细胞介素-6及选定的蛋白质组学生物标志物进行检测。评估每种标志物单独或联合使用时对羊膜腔内感染、早产及新生儿综合发病情况的预测价值。
白细胞介素-6（比值比，19.5；P = 0.012）和蛋白质组学生物标志物（比值比，25.2；P = 0.001）均为羊膜腔内感染的统计学独立预测指标。当仅存在1种标志物时，其敏感性、阳性预测值和假阳性率分别为25%﹑17.6%和20%；当两种标志物均被检测到时，上述指标分别为75%﹑75%和4.3%。二者联合使用并不能改善对早产或新生儿发病情况的预测。
蛋白质组学生物标志物与白细胞介素-6联合用于预测羊膜腔内感染时，其准确性优于单独使用。
