Legry Vanessa, Cottel Dominique, Ferrières Jean, Arveiler Dominique, Andrieux Nicolas, Bingham Annie, Wagner Aline, Ruidavets Jean-Bernard, Ducimetière Pierre, Amouyel Philippe, Meirhaeghe Aline
INSERM, U744, Lille, France.
Metabolism. 2009 Jul;58(7):971-5. doi: 10.1016/j.metabol.2009.02.019.
We investigated the association between the rs9939609 (T>A) polymorphism in the FTO (fat mass- and obesity-associated) gene and obesity- and type 2 diabetes mellitus-related phenotypes in the French Multinational MONItoring of Trends and Determinants in CArdiovascular Disease (MONICA) Study (n = 3367). In the study, TA or AA subjects had higher body mass index (BMI) (P = .017), waist circumference (P = .017), and hip (P = .01) circumference in an A allele dose-dependent manner. The A allele was also significantly associated with higher plasma insulin levels (P = .05), higher insulin resistance index (homeostasis model assessment) (P = .02), and higher systolic blood pressure (P = .003); but these associations disappeared after adjustment for BMI. In the study, 598 subjects were obese (BMI >or=30 kg/m(2)); and 2769 subjects were not obese (BMI <30 kg/m(2)). Subjects bearing the A allele of rs9939609 had a higher risk of obesity (adjusted odds ratio [95% confidence interval] = 1.29 [1.06-1.58], P = .01) compared with TT subjects. Moreover, the homozygous AA genotype of rs9939609 was associated with a higher risk of type 2 diabetes mellitus (odds ratio = 1.45 [1.05-1.99], P = .02, 283 subjects with and 2601 subjects without type 2 diabetes mellitus), independently of BMI. In conclusion, the role of the A allele of the FTO rs9939609 polymorphism on the risk of obesity and type 2 diabetes mellitus was confirmed in the French MONICA Study.
我们在法国多中心心血管疾病趋势和决定因素监测（MONICA）研究（n = 3367）中，调查了FTO（肥胖相关）基因中rs9939609（T>A）多态性与肥胖及2型糖尿病相关表型之间的关联。在该研究中，携带TA或AA基因型的受试者，其体重指数（BMI）（P = 0.017）、腰围（P = 0.017）和臀围（P = 0.01）以A等位基因剂量依赖的方式更高。A等位基因还与更高的血浆胰岛素水平（P = 0.05）、更高的胰岛素抵抗指数（稳态模型评估）（P = 0.02）和更高的收缩压（P = 0.003）显著相关；但在对BMI进行校正后，这些关联消失。在该研究中，598名受试者肥胖（BMI≥30 kg/m²）；2769名受试者不肥胖（BMI<30 kg/m²）。与TT基因型受试者相比，携带rs9939609 A等位基因的受试者肥胖风险更高（校正优势比[95%置信区间]=1.29[1.06 - 1.58]，P = 0.01）。此外，rs9939609的纯合AA基因型与2型糖尿病风险更高相关（优势比=1.45[1.05 - 1.99]，P = 0.02，283名患有2型糖尿病和2601名未患2型糖尿病的受试者），且独立于BMI。总之，在法国MONICA研究中证实了FTO rs9939609多态性的A等位基因在肥胖和2型糖尿病风险中的作用。
