Perez-Luque Elva, Daza-Hernandez Edgar S, Figueroa-Vega Nicte, Cardona-Alvarado Monica I, Muñoz-Montes Norberto, Martinez-Cordero Claudia
Departamento de Ciencias Médicas, Campus León, Universidad de Guanajuato, León 37320, Guanajuato, Mexico.
Hospital Regional de Alta Especialidad del Bajío, León 37660, Guanajuato, Mexico.
Genes (Basel). 2024 Mar 22;15(4):391. doi: 10.3390/genes15040391.
Bariatric surgery (BS) is considered the most effective intervention for patients with severe obesity and is used to maintain long-term weight loss and glycemic control. The aim of this study was to analyze the effects of genotypes and haplotypes of the fat mass and obesity-associated () and melanocortin 4 receptor ( genes on total body weight loss (TBWL), post-surgery weight, and post-BMI after bariatric surgery. We retrospectively selected 101 patients from Bajio High Specialty Regional Hospital, León Guanajuato, México, who underwent Roux-en-Y gastric bypass (RYGB) to determine their body mass index (BMI), blood pressure, biochemical characteristics, and comorbidities. Post-surgery, patients were referred for registered anthropometry and blood pressure. Glucose, lipid and hepatic profiles, and insulin, leptin, and ghrelin levels were measured, and rs9939609, rs9930506, and rs1421085 and rs17782313 polymorphisms were genotyped. Six (4-8) years after BS, post-surgery weight was greater in carriers of the rs9939609 and rs1421085 risk genotypes. TBWL was lower for the rs9930506 and rs1421085 risk genotypes. Insulin and HOMA-IR were greater in patients with the three polymorphisms. There were significant interaction effects of the rs9930506 and rs1421085 risk genotypes on weight and BMI in response to BS. No association was found with the polymorphism. The genotypes and haplotypes of the gene influence post-surgery weight, TBWL, insulin levels, and HOMA-IR.
减肥手术（BS）被认为是治疗重度肥胖患者最有效的干预措施，用于维持长期体重减轻和血糖控制。本研究的目的是分析脂肪量和肥胖相关基因（ ）以及黑皮质素4受体（ ）基因的基因型和单倍型对减肥手术后总体重减轻（TBWL）、术后体重和术后BMI的影响。我们回顾性地从墨西哥瓜纳华托州莱昂市巴希奥高级专科医院选取了101例行Roux-en-Y胃旁路术（RYGB）的患者，以确定他们的体重指数（BMI）、血压、生化特征和合并症。术后，患者接受登记的人体测量和血压测量。测量血糖、血脂和肝功能指标，以及胰岛素、瘦素和胃饥饿素水平，并对rs9939609、rs9930506、rs1421085和rs17782313多态性进行基因分型。减肥手术后6（4 - 8）年，rs9939609和rs1421085风险基因型携带者的术后体重更大。rs9930506和rs1421085风险基因型的TBWL较低。具有这三种多态性的患者胰岛素和HOMA-IR更高。rs9930506和rs1421085风险基因型对减肥手术的体重和BMI有显著的交互作用。未发现与 多态性有关联。 基因的基因型和单倍型影响术后体重、TBWL、胰岛素水平和HOMA-IR。
