尼日利亚东北部迈杜古里成人淋巴瘤的血液系统恶性肿瘤谱及生存结果——一项十四年回顾

Spectrum of haematologic malignancies and survival outcomes of adult lymphomas in Maiduguri, north eastern Nigeria--a fourteen year review.

作者信息

Kagu M B, Ahmed S G, Bukar A A, Mohammed A A, Mayun A A, Musa A B

机构信息

Department of Haematology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.

出版信息

Afr J Med Med Sci. 2013 Mar;42(1):5-14.

PMID:23909089

Abstract

BACKGROUND

The incidence of Haematologic malignancies has been shown to vary according to gender, age, geographic region, and histologic subtypes, while cure rates can vary according to region and may be impacted by treatment availability and access to care.

METHOD

This was an institution based review of data from the Medical Records Department, Department of Haematology and Cancer Registry of the Histopathology Department of the University of Maiduguri Teaching Hospital between January 1998 and December 2011. The aim was to study the spectrum of Haematologic malignancies and the survival pattern of adult lymphomas in this region and to compare our findings to studies reported elsewhere.

RESULTS

The Haematologic malignancies represented 6.05% of all cancer cases seen and 0.31% of hospital admissions. Among the Haematologic malignancies, Non-Hodgkins Lymphoma (NHL) was the most frequent, constituting 51.3% while others include: Hodgkins Lymphoma (HL), 26.7% Chronic Myeloid Leukaemia (CML), 5.5%, Acute Myeloblastic leukaemia (AML), 4.2% Multiple Myeloma (MM), 4.2% Acute Lymphoblastic leukaemia (ALL), 3.8%, Chronic Lymphocytic Leukaemia (CLL), 3.4% Myelodysplastic Syndrome (MDS), 0.4% and Chronic Myelofibrosis 0.4%. Haematologic malignancies are more common in younger age group and also more common in males than females. Lymphomas are particularly common in young adults and the incidence tends to fall after 70 years. Similarly, the characteristic bimodal age incidence for HL found in western world has not been seen in this study. The histological subtypes for both NHL and HL are similar to the pattern reported elsewhere. Default rate was high and we found a strong association between cycles of chemotherapy given and survival in lymphoma patients.

CONCLUSION

This study has shown that Haematologic malignancies are not uncommon in our environment. There is need to provide basic facilities and training for immunophenotyping and immunohistochemistry in all cancer treatment centers across the country. Cytotoxic drugs must be subsidized and also be made readily available to all patients with Haematologic malignancies.

摘要

背景

血液系统恶性肿瘤的发病率因性别、年龄、地理区域和组织学亚型而异，而治愈率可能因地区不同而有所差异，并且可能受到治疗可及性和医疗服务获取情况的影响。

方法

这是一项基于迈杜古里大学教学医院病历科、血液科以及组织病理学系癌症登记处1998年1月至2011年12月数据的机构性回顾研究。目的是研究该地区血液系统恶性肿瘤的种类以及成人淋巴瘤的生存模式，并将我们的研究结果与其他地方报道的研究进行比较。

结果

血液系统恶性肿瘤占所有癌症病例的6.05%，占住院病例的0.31%。在血液系统恶性肿瘤中，非霍奇金淋巴瘤（NHL）最为常见，占51.3%，其他包括：霍奇金淋巴瘤（HL），26.7%；慢性髓性白血病（CML），5.5%；急性髓细胞白血病（AML），4.2%；多发性骨髓瘤（MM），4.2%；急性淋巴细胞白血病（ALL），3.8%；慢性淋巴细胞白血病（CLL），3.4%；骨髓增生异常综合征（MDS），0.4%；慢性骨髓纤维化，0.4%。血液系统恶性肿瘤在较年轻年龄组中更为常见，男性比女性更常见。淋巴瘤在年轻人中尤为常见，发病率在70岁以后往往会下降。同样，本研究未发现西方世界中HL特有的双峰年龄发病率。NHL和HL的组织学亚型与其他地方报道的模式相似。违约率很高，并且我们发现淋巴瘤患者接受的化疗周期数与生存率之间存在密切关联。