Departamento de Medicina Experimental Facultad de Medicina, Universidad Nacional Autónoma de México, México DF, Mexico.
Infect Genet Evol. 2009 Dec;9(6):1033-7. doi: 10.1016/j.meegid.2009.04.005. Epub 2009 Apr 17.
For many years virulence of pathogenic Entamoeba histolytica has been attributed to the capacity of the parasite to destroy tissues through the expression and/or secretion of various molecules. Such view is supported mainly by in vitro experimentation, whereas data obtained by using animal models of the disease have clearly demonstrated that the host's inflammatory response is primarily responsible for tissue damage. This review analyzes the content and/or activity of some of the presumed toxic amebic molecules present in amebic strains with different degrees of virulence compared to various parasite in vitro functions that are supposed to correlate with in vivo virulence. The analysis suggests that amebic virulence is primarily determined by the parasite's capacity to adapt and survive the aerobic conditions present in animal tissues. This initial episode in the host-parasite relationship is an absolute requirement for the further development of tissue lesions, which result from the concerted action of many molecules derived from both, the host and the parasite.
多年来，致病性溶组织内阿米巴的毒力一直归因于寄生虫通过表达和/或分泌各种分子来破坏组织的能力。这种观点主要得到了体外实验的支持，而通过疾病动物模型获得的数据清楚地表明，宿主的炎症反应是组织损伤的主要原因。本文分析了与体内毒力相关的各种体外寄生虫功能相比，不同毒力溶组织内阿米巴株中某些假定有毒阿米巴分子的含量和/或活性。分析表明，阿米巴毒力主要取决于寄生虫适应和在动物组织中存在的需氧条件的能力。宿主-寄生虫关系的这一初始阶段是进一步发展组织损伤的绝对要求，这是宿主和寄生虫来源的许多分子协同作用的结果。
