Department of Obstetrics, Gynecology, and Reproductive Biology and Department of Epidemiology, Michigan State University, B227 West Fee Hall, East Lansing, Michigan 48824, USA.
Fertil Steril. 2010 Feb;93(2):490-8. doi: 10.1016/j.fertnstert.2009.02.077. Epub 2009 Apr 18.
To evaluate factors associated with the use of elective single embryo transfer (eSET) and its effect on assisted reproductive technology (ART) outcome.
Historical cohort.
Clinic-based data.
PATIENT(S): A total of 69,028 ART cycles of autologous fresh embryo transfers with additional embryos cryopreserved during the same cycle performed during 2004-06 and reported to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Factors associated with the number of embryos transferred, and the odds of pregnancy, live birth, and multiple-infant live birth by number of embryos transferred as adjusted odds ratios (AORs).
RESULT(S): Single embryo transfer was used more with uterine factor (AOR 1.76) and less with male factor, endometriosis, or tubal factor (AOR 0.81, 0.72, 0.83, respectively). Compared with women aged <30 years, eSET was used less among women aged 35-39 years and > or =40 years (AOR 0.74 and 0.39, respectively). Compared with White women, eSET was used more with Asian (AOR 1.52) and less with Black or Hispanic women (AOR 0.73 and 0.67, respectively). Compared with eSET, the likelihood of pregnancy, live birth, or multiple-infant live birth was more likely with two embryos (AOR 1.33, 1.34, and 27.4, respectively).
CONCLUSION(S): Elective SET, used more for younger women with specific diagnoses, is associated with slightly reduced likelihood of a live birth but much reduced likelihood of multiples.
评估与选择性单胚胎移植（eSET）使用相关的因素及其对辅助生殖技术（ART）结局的影响。
历史队列研究。
基于临床的数据。
2004-06 年期间在同一周期内进行的、且向辅助生殖技术协会临床结局报告系统数据库报告的共 69028 个自体新鲜胚胎移植的 ART 周期，这些周期中额外的胚胎被冷冻保存。
无。
与胚胎移植数量相关的因素，以及根据胚胎移植数量调整的 odds ratio（AOR）来评估妊娠、活产和多胎活产的可能性。
eSET 更多地用于子宫因素（AOR 1.76），而较少用于男性因素、子宫内膜异位症或输卵管因素（AOR 分别为 0.81、0.72、0.83）。与<30 岁的女性相比，eSET 在 35-39 岁和≥40 岁的女性中使用较少（AOR 分别为 0.74 和 0.39）。与白人女性相比，eSET 在亚洲女性中使用较多（AOR 1.52），在黑人或西班牙裔女性中使用较少（AOR 分别为 0.73 和 0.67）。与 eSET 相比，双胚胎移植更有可能导致妊娠、活产或多胎活产（AOR 分别为 1.33、1.34 和 27.4）。
eSET 主要用于特定诊断的年轻女性，其活产的可能性略有降低，但多胎的可能性大大降低。
