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与非西班牙裔白人女性相比,西班牙裔和亚裔女性接受抗逆转录病毒治疗后的活产率及累积活产结局的差异。

Disparities in ART Live Birth and Cumulative Live Birth Outcomes for Hispanic and Asian Women Compared to White Non-Hispanic Women.

作者信息

Kotlyar Alexander M, Simsek Burcin, Seifer David B

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USA.

Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15260, USA.

出版信息

J Clin Med. 2021 Jun 14;10(12):2615. doi: 10.3390/jcm10122615.

Abstract

BACKGROUND

Conflicting disparities have been seen in assisted reproductive technology (ART) outcomes for Hispanic and Asian women compared to white, non-Hispanic (WNH) women. We, therefore, sought to clarify these disparities and calculated cumulative live birth rates (CLBR) for these racial or ethnic groups using the SARTCORS database.

METHODS

We performed an analysis of the 2014-2016 SARTCORS database for member clinics doing at least 50 cycles of ART each year.

RESULTS

In comparison to cycles in WNH women, cycles in Hispanic and Asian patients were in older ( < 0.001), more nulliparous women, that were less likely to have a history of endometriosis compared WNH women regardless of prior ART status. ART cycles in Hispanic and Asian women, exhibited lower rates of live birth (LB) per cycle start ( < 0.001) compared to cycles in WNH women. Multivariate logistic regression demonstrated that cycles from Hispanic and Asian women were less likely to have a LB and CLBR than white women (OR 0.86; = 0.004, OR 0.69; < 0.001, respectively) independent of age, parity, BMI, etiology of infertility, use of ICSI or number of embryos transferred.

CONCLUSIONS

Race or ethnicity continues to be an independent prognostic factor for LB and CLBR for ART. Additional analysis of trends among Hispanic and Asian women is warranted to enable addressing disparities in outcomes in ART treatment.

摘要

背景

与非西班牙裔白人(WNH)女性相比,西班牙裔和亚裔女性在辅助生殖技术(ART)治疗结果上存在相互矛盾的差异。因此,我们试图通过使用SART CORS数据库来明确这些差异,并计算这些种族或族裔群体的累积活产率(CLBR)。

方法

我们对2014 - 2016年SART CORS数据库中每年至少进行50个ART周期的成员诊所进行了分析。

结果

与WNH女性的周期相比,西班牙裔和亚裔患者的周期中女性年龄更大(P < 0.001),初产妇更多,无论既往ART状态如何,与WNH女性相比,患子宫内膜异位症的可能性更小。与WNH女性的周期相比,西班牙裔和亚裔女性的ART周期每周期开始时的活产(LB)率更低(P < 0.001)。多因素逻辑回归显示,与白人女性相比,西班牙裔和亚裔女性的周期获得活产和CLBR的可能性更小(OR分别为0.86,P = 0.004;OR为0.69,P < 0.001),独立于年龄、产次、BMI、不孕病因、ICSI的使用或移植胚胎数量。

结论

种族或族裔仍然是ART活产和CLBR的独立预后因素。有必要对西班牙裔和亚裔女性的趋势进行进一步分析,以解决ART治疗结果中的差异问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a38c/8231797/35b7553f6566/jcm-10-02615-g001.jpg

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