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SECRITT I试验中首例易损斑块支架置入术——新时代的曙光?

First case of stenting of a vulnerable plaque in the SECRITT I trial-the dawn of a new era?

作者信息

Ramcharitar Steve, Gonzalo Nieves, van Geuns Robert Jan, Garcia-Garcia Hector M, Wykrzykowska Joanna J, Ligthart Jurgen M R, Regar Evelyn, Serruys Patrick W

机构信息

Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam 3015 GD, The Netherlands.

出版信息

Nat Rev Cardiol. 2009 May;6(5):374-8. doi: 10.1038/nrcardio.2009.34.

Abstract

BACKGROUND

A 63-year-old man presented with class II anginal symptoms.

INVESTIGATIONS

Cardiac catheterization, intravascular ultrasound (IVUS) virtual histology, optical coherence tomography and off-line palpography.

DIAGNOSIS

The patient was diagnosed as having a culprit lesion in the left circumflex artery and a vulnerable plaque in the left anterior descending artery.

MANAGEMENT

The culprit lesion was treated with two overlapping drug-eluting stents. The vulnerable plaque was then treated with a self-expanding stent tailored to shield vulnerable plaques (vProtect Luminal Shield). After dilatation of the stent with a low-pressure balloon, IVUS and optical coherence tomography showed excellent apposition of the stent to the vessel wall, with no signs of tissue prolapse or edge dissections. At the 6-month follow-up appointment, the stent showed complete tissue coverage without signs of in-stent restenosis.

CONCLUSIONS

Six months of follow-up has demonstrated that a patient with an IVUS-derived, thin capped fibroatheroma was successfully treated with a stent tailored to shield vulnerable plaques.

摘要

背景

一名63岁男性出现II级心绞痛症状。

检查

心脏导管插入术、血管内超声(IVUS)虚拟组织学、光学相干断层扫描和离线触诊法。

诊断

患者被诊断为左旋支动脉有罪犯病变,左前降支动脉有易损斑块。

治疗

罪犯病变采用两个重叠的药物洗脱支架治疗。然后用定制的用于保护易损斑块的自膨胀支架(vProtect管腔护盾)治疗易损斑块。用低压球囊扩张支架后,IVUS和光学相干断层扫描显示支架与血管壁贴合良好,无组织脱垂或边缘夹层迹象。在6个月的随访预约中,支架显示完全被组织覆盖,无支架内再狭窄迹象。

结论

6个月的随访表明,一名经IVUS诊断为薄帽纤维粥样瘤的患者成功接受了定制的用于保护易损斑块的支架治疗。

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